Survodutide

Survodutide

$144.99

Survodutide 10 mg

What is SURV

Survodutide (10 mg) is supplied strictly for laboratory research and analytical applications, commonly referenced in metabolic pathway and receptor signaling studies.

Specifications:
  • Strength: 10 mg per vial
  • Format: Lyophilized powder
  • Category: Fat Loss & Metabolism
  • Documentation: COA available

Research Use Only — Not for Human Consumption.

1000 in stock

SKU: VE-SURV-010 Category:

Description

  • About Survodutide

    Survodutide — also known as BI 456906 (CAS 2361157-75-5) — is a dual GLP-1/glucagon receptor co-agonist (dual GLP-1R/GCGR agonist) developed by Boehringer Ingelheim, with a C18 fatty acid chain enabling albumin binding and extended half-life. It is supplied as a laboratory-grade lyophilized powder intended strictly for analytical and non-clinical research applications.

    Unlike tirzepatide (GIP/GLP-1) or retatrutide (GIP/GLP-1/glucagon triple agonist), survodutide s dual GLP-1R/GCGR mechanism specifically combines GLP-1R-mediated insulin secretion and appetite suppression with GCGR-mediated increases in energy expenditure and hepatic fatty acid oxidation — making it a particularly relevant tool compound for studying NASH/MAFLD, obesity-related hepatic steatosis, and energy expenditure pathway research. Researchers use survodutide in hepatocyte, adipocyte (3T3-L1, primary), and hypothalamic neuron models to study GLP-1R/GCGR co-activation, hepatic lipid metabolism (PPAR-α, FGF21, CPT1 expression), glucagon receptor cAMP/PKA/CREB signaling, and comparative incretin axis pharmacology.

    COMMON RESEARCH APPLICATIONS

    Dual GLP-1R/GCGR Co-Activation Pharmacology
    Used in HEK293-GLP1R, HEK293-GCGR, and primary hepatocyte models to characterize simultaneous GLP-1R and GCGR receptor activation kinetics, cAMP accumulation dose-response at each receptor, and receptor cross-talk in co-expressing systems.

    Hepatic Lipid Metabolism & MAFLD Pathway Research
    Survodutide s GCGR component drives hepatic fatty acid β-oxidation (CPT1A upregulation, PPAR-α activation) and FGF21 secretion. Used in HepG2, AML12, and primary hepatocyte models under oleic acid loading to study lipid droplet reduction and steatosis pathway markers.

    Energy Expenditure & Brown Adipose Signaling
    GCGR activation increases thermogenic gene expression (UCP-1, PGC-1α) in brown adipocyte and BAT-derived cell models. Used alongside GLP-1R-only agonists to isolate the additional thermogenic contribution of glucagon receptor co-activation vs. GLP-1R alone.

    Comparative Incretin Polypharmacology Benchmarking
    Benchmarked against tirzepatide (GIP/GLP-1), retatrutide (GIP/GLP-1/glucagon), semaglutide (GLP-1 only), and cotadutide (GLP-1/glucagon) to map the specific contribution of GLP-1R + GCGR dual activation across incretin axis receptor combinations.

  • Chemical Identity

    Compound Name: Survodutide

    Internal Catalog Code: Survodutide

    CAS Number: 2361157-75-5

    Molecular Formula: C174H271N47O52

    Molecular Weight: 3846.33 g/mol

    Physical Properties

    Form/Appearance: Lyophilized powder

    Quality & Testing

    Purity: As listed on lot-specific COA

    Testing Method : HPLC (as applicable) · identity confirmation per COA

    Verification

    COA: Lot-specific, included with order (QR on label)

    Handling & Storage

    Storage Temperature: Store desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.

    Light Sensitivity: Protect from light

    Moisture: Store desiccated when applicable

    Available Strengths: 10 mg

    SKU (10 mg): VE-SURV-010

    • What is this product?
      Survodutide (BI 456906, CAS 2361157-75-5, MW 3846.33 g/mol, C₁₇₄H₂₇₁N₄₇O₅₂) is supplied as a lyophilized dual GLP-1R/GCGR co-agonist peptide for laboratory research use only. Available as VE-SURV-010 (10 mg).
    • What purity and testing methods are used?
      Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity with sequence verification. A lot-specific COA is included with every order, accessible via QR code on the label.
    • What are the key chemical identifiers?
      CAS 2361157-75-5 · Molecular formula C₁₇₄H₂₇₁N₄₇O₅₂ · MW 3846.33 g/mol · Synonyms: BI 456906, dual GLP-1/glucagon receptor co-agonist, GLP-1R/GCGR agonist.
    • How is survodutide reconstituted for research use?
      Dissolve in sterile water or PBS (pH 7.4) at ~1 mg/mL. Avoid repeated freeze-thaw cycles. Store desiccated at −20°C long-term. Protect from light
    • What is the recommended storage upon receipt?
      Store immediately at −20°C desiccated. Short-term 2–8°C acceptable. Inspect vials for integrity upon receipt
    • What is a COA and why does it matter?
      A COA documents lot-specific purity (HPLC ≥98%), identity (MS), and sequence verification. Each survodutide lot ships with a QR-accessible COA. Review before use to confirm identity and purity meet your experimental requirements for receptor co-activation studies.

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