Description
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About Tirzepatide (Mounjaro® active ingredient)
Tirzepatide — the active peptide in Mounjaro® (CAS 2023788-19-2) — is a first-in-class dual GIP/GLP-1 receptor agonist (the "twincretin") with a C20 fatty diacid chain enabling albumin binding and once-weekly dosing pharmacokinetics (~5-day half-life). It co-activates both the glucose-dependent insulinotropic polypeptide receptor (GIPR) and the glucagon-like peptide-1 receptor (GLP-1R), producing additive or synergistic effects on insulin secretion and energy homeostasis compared to selective GLP-1R agonists. Used in research to dissect the relative contributions of GIP and GLP-1 signaling in metabolic regulation, β-cell function, and CNS appetite pathways. Supplied as lyophilized peptide for non-clinical research use only. Internal catalog code: VE-TIRZ.
COMMON RESEARCH APPLICATIONS
Dual GIP/GLP-1 Receptor Pharmacology
Tirzepatide activates both GIPR and GLP-1R with balanced potency. Used to compare dual vs. selective agonism in cAMP signaling, β-arrestin recruitment, and receptor internalization in HEK293 cell models co-expressing GIPR and GLP-1R.β-Cell Function Research
Tool compound for studying augmented insulin secretion through dual incretin receptor activation in INS-1 and MIN6 pancreatic β-cell models; distinguishing GIP vs. GLP-1 contribution at different glucose concentrations.Metabolic & Adipose Tissue Studies
GIPR activation in adipose tissue drives lipolysis modulation; used to study fat depot dynamics, FFA flux, and lipid metabolism in adipocyte cell models alongside GLP-1R-driven CNS effects.Comparative GLP-1R Agonist Benchmarking
Reference standard for comparing dual GIPR/GLP-1R agonism vs. selective GLP-1R agonists (semaglutide) and triple agonists (retatrutide) in the same experimental system. -
Chemical Identity
Compound Name: Tirzepatide
Synonyms: Mounjaro active ingredient · LY3298176 · GIP/GLP-1 dual agonist · twincretin
CAS Number: 2023788-19-2
EC Number: N/A (synthetic peptide)
Molecular Formula: C₂₂₅H₃₄₈N₄₈O₆₈S
Molecular Weight: 4813.50 g/mol
Internal Catalog Code: VE-TIRZ
Physical Properties
Appearance: White to off-white lyophilized powder
Solubility (water): ~1 mg/mL in sterile water or PBS (pH 7.4)
Solubility (organic): Soluble in DMSO (~5 mg/mL)
Hygroscopic: Yes — store desiccated
Quality & Testing
Purity: ≥98% (HPLC)
Testing Method : Reverse-phase HPLC · MS confirmation · sequence verification
Verification
COA: Lot-specific, included with order (QR on label)
SDS Supplier : See SDS/MSDS · OSHA HCS / GHS compliant
Handling & Storage
Storage Temperature: Store desiccated at −20°C long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.
Light Sensitivity: Protect from light
Reconstitution: Dissolve in sterile water or PBS (pH 7.4); avoid repeated freeze-thaw cycles
Available Strengths: 5 mg · 10 mg · 15 mg · 20 mg · 30 mg · 40 mg · 50 mg · 60 mg · 120 mg
SKU (5 mg): VE-TIRZ-005
SKU (10 mg): VE-TIRZ-010
SKU (15 mg): VE-TIRZ-015
SKU (20 mg): VE-TIRZ-020
SKU (30 mg): VE-TIRZ-030
SKU (40 mg): VE-TIRZ-040
SKU (50 mg): VE-TIRZ-050
SKU (60 mg): VE-TIRZ-060
SKU (120 mg): VE-TIRZ-120
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What is this product?
Tirzepatide (VE-TIRZ) is supplied as a lyophilized dual GIP/GLP-1 receptor agonist peptide (CAS 2023788-19-2, MW 4813.50 g/mol) intended for laboratory research use only. It is the active peptide in Mounjaro® and Zepbound®.
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What purity and testing methods are used?
Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity. A lot-specific COA is included with every order. Scan the QR code on the label to access your lot documentation.
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What are the key chemical identifiers?
CAS 2023788-19-2 · Molecular formula C₂₂₅H₃₄₈N₄₈O₆₈S · MW 4813.50 g/mol · Synonyms: LY3298176, Mounjaro active ingredient, GIP/GLP-1 dual agonist, twincretin.
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How is tirzepatide reconstituted for research use?
Dissolve in sterile water or PBS (pH 7.4) at ~1 mg/mL. DMSO (~5 mg/mL) is suitable for organic applications. Store desiccated at −20°C long-term. Avoid repeated freeze-thaw cycles. Protect from light.
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How does tirzepatide differ from semaglutide in research applications?
Semaglutide selectively activates GLP-1R; tirzepatide co-activates both GLP-1R and GIPR. This dual mechanism makes tirzepatide useful for studies comparing incretin receptor contributions and for benchmarking downstream signaling differences in the same cell model.
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What is the recommended storage upon receipt?
Store immediately at −20°C in a desiccated environment upon receipt. Short-term at 2–8°C is acceptable. Do not leave at room temperature. Inspect the vial for integrity and contact support if damaged.
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What is a COA and why does it matter?
A COA documents lot-specific analytical results including purity (HPLC ≥98%), identity (MS confirmation), and appearance. Each VE-TIRZ lot ships with a QR-accessible COA. Review before use to confirm identity and purity meet your experimental requirements.
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What is this product?
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