AOD-9604

AOD-9604

$92.00

AOD-9604 5 mg

What is AODX

AOD-9604 (5 mg) is supplied strictly for laboratory research and analytical applications, commonly referenced in metabolic pathway and receptor signaling studies.

Specifications:
  • Strength: 5 mg per vial
  • Format: Lyophilized powder
  • Category: Fat Loss & Metabolism
  • Documentation: COA available

Research Use Only — Not for Human Consumption.

SKU: VE-AODX-96045 Category:

Description

  • About AOD)

    AOD-9604 — also known as hGH fragment 176–191 (CAS 221231-10-3) — is a synthetic 16-amino acid peptide corresponding to the C-terminal lipolytic domain of human growth hormone. It is supplied as a laboratory-grade lyophilized powder intended strictly for analytical and non-clinical research applications.

    Unlike full-length hGH, AOD-9604 retains the lipolytic signaling domain (residues 176–191) without engaging the IGF-1 or insulin receptor pathways, making it a clean tool compound for isolating fat metabolism signaling in adipocyte models. Researchers use AOD-9604 in 3T3-L1 and primary adipocyte cell systems to study β3-adrenergic receptor activation, hormone-sensitive lipase (HSL) pathway modulation, and lipolysis-related gene expression under controlled laboratory conditions.

    COMMON RESEARCH APPLICATIONS

    Adipocyte Lipolysis Models
    AOD-9604 is used in 3T3-L1 adipocyte differentiation and lipolysis assays to study β3-adrenergic receptor activation, HSL phosphorylation, and free fatty acid / glycerol release as quantifiable pathway endpoints.

    Fat Metabolism Pathway Screening
    Examined in metabolic gene expression panels (ATGL, HSL, perilipin) across adipocyte and pre-adipocyte models to characterize lipolysis pathway selectivity relative to full-length hGH and β3-agonist reference compounds.

    IGF-1–Independent GH Signaling Research
    Used to delineate IGF-1-independent versus IGF-1-dependent growth hormone effects. AOD-9604 does not engage GHR/JAK2/STAT5 signaling, making it a useful negative control in GHR pathway studies.

    Comparative Peptide Fragment Studies
    Benchmarked alongside AOD-9604 + L-Carnitine blends and other lipolytic peptide fragments to evaluate additive or complementary effects on mitochondrial fatty acid transport and energy substrate utilization.

  • Chemical Identity

    Compound Name: AOD-9604

    Synonyms: AOD9604 · hGH fragment 176–191 · Anti-Obesity Drug 9604 · Tyr-hGH(177–191)

    CAS Number: 221231-10-3

    EC Number: N/A (synthetic peptide — hGH C-terminal fragment)

    Molecular Formula: C78H123N23O23S2

    Molecular Weight: 1815.08 g/mol

    Physical Properties

    Appearance: White to off-white lyophilized powder

    Solubility (water): ~2 mg/mL in sterile water or PBS (pH 7.4)

    Solubility (organic): Limited; DMSO (~1 mg/mL)

    Hygroscopic: Yes — store desiccated

    Quality & Testing

    Purity: ≥98% (HPLC)

    Testing Method : Reverse-phase HPLC · MS confirmation · sequence verification

    Verification

    COA: Lot-specific, included with order (QR on label)

    SDS Supplier : Velox Research Chemicals

    SDS Revision: Current lot · OSHA HCS / GHS compliant

    Handling & Storage

    Storage Temperature: Store desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling

    Light Sensitivity: Protect from light

    Reconstitution: Dissolve in sterile water or PBS (pH 7.4); use immediately or aliquot and store at −80°C

    Available Strengths: 5 mg · 10 mg

    SKU (5 mg): VE-AODX-005

    SKU (10 mg): VE-AODX-010

    • What is this product?
      AOD-9604 (CAS 221231-10-3, MW 1815.08 g/mol) is a synthetic 16-amino acid peptide — the C-terminal fragment (residues 176–191) of human growth hormone — supplied as a lyophilized powder for laboratory research use only. Also known as hGH fragment 176–191 or Anti-Obesity Drug 9604.
    • What purity and testing methods are used?
      Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity with sequence verification. A lot-specific COA is included with every order, accessible via QR code on the label.
    • What are the key chemical identifiers?
      CAS 221231-10-3 · Molecular formula C₇₈H₁₂₃N₂₃O₂₃S₂ · MW 1815.08 g/mol · Synonyms: AOD9604, hGH fragment 176–191, Anti-Obesity Drug 9604.
    • What signaling pathways does AOD-9604 address in research models?
      AOD-9604 is studied in lipolysis and adipocyte biology models including β3-adrenergic receptor activation, hormone-sensitive lipase (HSL) phosphorylation, and ATGL/perilipin pathway research. Notably, it does not engage the IGF-1 or JAK2/STAT5 signalling axes, making it selective for the lipolytic hGH domain.
    • How is AOD-9604 reconstituted for research use?
      Dissolve in sterile water or PBS (pH 7.4) at ~2 mg/mL. Use immediately or aliquot and store at −80°C to prevent degradation. Avoid repeated freeze-thaw cycles. Protect from light.
    • What is the recommended storage upon receipt?
      Store immediately at −20°C desiccated. For long-term stability, −80°C is preferred. Short-term at 2–8°C is acceptable for up to 2 weeks. Inspect vials for integrity upon receipt.
    • What is a COA and why does it matter?
      A COA documents lot-specific purity (HPLC ≥98%), sequence verification (MS), and appearance. Each lot ships with a QR-accessible COA. Review before use to confirm identity and purity meet your experimental requirements.

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