HCG

HCG

Price range: $50.00 through $146.00

HCGX 2000 IU / 5000 IU / 10000 IU

What is HCGX

HCG is supplied strictly for laboratory research and analytical applications, commonly referenced in endocrine axis, organ-signaling, and regulatory pathway studies.

Specifications:
  • Strength: 10000 IU per vial
  • Format: Lyophilized powder
  • Category: Cellular & Regulatory Signaling
  • Documentation: COA available

Research Use Only — Not for Human Consumption.

SKU: N/A Category:

Description

  • About HCG

    Human Chorionic Gonadotropin (hCG, CAS 9002-61-3) is a heterodimeric glycoprotein hormone (~36,700 g/mol) consisting of a non-covalently associated α-subunit (shared with LH, FSH, and TSH) and a unique hCG β-subunit that confers LH-receptor binding specificity. It is supplied as a laboratory-grade lyophilized preparation intended strictly for analytical and non-clinical research applications.

    HCG is the most potent natural ligand for the LH/hCG receptor (LHCGR), a Gs-coupled GPCR expressed on Leydig cells, theca cells, and corpus luteum. Due to its substantially longer half-life than LH (~24–36 hours versus ~20 minutes for pituitary LH), hCG has become the standard tool compound in LHCGR pharmacology and steroidogenesis research. Researchers use hCG in Leydig cell (MA-10, MLTC-1), granulosa cell, and primary gonadal cell models to study LHCGR signaling (cAMP/PKA, ERK1/2), steroidogenic acute regulatory protein (StAR) activation, testosterone and progesterone biosynthesis pathway mapping, and receptor internalization kinetics.

    COMMON RESEARCH APPLICATIONS

    LHCGR Pharmacology & Steroidogenesis Research
    Primary LHCGR agonist in MA-10, MLTC-1, and primary Leydig cell models. Used to study cAMP/PKA-mediated steroidogenic pathway activation, StAR protein expression, CYP11A1/CYP17A1 enzyme induction, and testosterone biosynthesis kinetics.

    Granulosa Cell & Ovarian Signaling
    Used in KGN and primary granulosa cell models to study LH surge-mimicking LHCGR activation, progesterone synthesis (HSD3B2, CYP11A1 induction), and ERK1/2 co-signaling in luteinization pathway research.

    LHCGR Receptor Internalization & Desensitization Studies
    Prolonged half-life vs. pituitary LH makes hCG the preferred tool for studying LHCGR internalization kinetics, β-arrestin recruitment, and receptor downregulation in sustained agonist exposure models.

    Comparative Gonadotropin Pharmacology
    Reference standard for comparing LHCGR activation potency and downstream signaling between hCG and recombinant LH (rLH); used in dose-response studies, receptor binding competition assays, and steroidogenesis pathway benchmarking.

  • Chemical Identity

    Compound Name: HCG

    Internal Catalog Code: HCG

    CAS Number: 9002-61-3

    Molecular Formula: Glycoprotein

    Molecular Weight: ~36,700 g/mol

    Physical Properties

    Form/Appearance: Lyophilized powder

    Quality & Testing

    Purity: As listed on lot-specific COA

    Testing Method : HPLC (as applicable) · identity confirmation per COA

    Verification

    COA: Lot-specific, included with order (QR on label)

    Handling & Storage

    Storage Temperature: Store desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.

    Light Sensitivity: Protect from light

    Moisture: Store desiccated when applicable

    Available Strengths: 2000 mg · 5000 mg · 10000 mg

    SKU (2000 mg): VE-HCGX-2000

    SKU (5000 mg): VE-HCGX-5000

    SKU (10000 mg): VE-HCGX-10000

    • What is this product?
      HCG (human chorionic gonadotropin, CAS 9002-61-3, ~36,700 g/mol) is supplied as a lyophilized heterodimeric glycoprotein hormone for laboratory research use only. It is the standard LHCGR agonist in gonadal steroidogenesis research. Available as VE-HCGX-2000 (2,000 IU), VE-HCGX-5000 (5,000 IU), and VE-HCGX-10000 (10,000 IU).
    • What purity and testing methods are used?
      Each lot is tested for biological activity (IU potency assay), identity confirmation, and glycoprotein integrity. A lot-specific COA documenting potency (IU) and identity is included with every order, accessible via QR code on the label.
    • What are the key chemical identifiers?
      CAS 9002-61-3 · Glycoprotein (α+β heterodimer) · MW ~36,700 g/mol · Synonyms: human chorionic gonadotropin, hCG, choriogonadotropin, LH/hCG receptor agonist.
    • Why is hCG used instead of LH in receptor signaling research?
      hCG has a substantially longer half-life (~24–36 h) compared to pituitary LH (~20 min) due to additional O-linked oligosaccharides on the β-subunit CTP region. This pharmacokinetic advantage makes hCG the preferred LHCGR agonist for sustained receptor stimulation protocols, steroidogenesis time-course studies, and in vitro Leydig/granulosa cell assays where controlled, prolonged receptor activation is required.
    • What is the recommended storage upon receipt?
      Store lyophilized material at −20°C in a desiccated environment. Short-term 2–8°C acceptable for active use. Inspect vials for integrity upon receipt. Once reconstituted, use promptly or store per COA guidance.
    • What is a COA and why does it matter?
      A COA documents lot-specific potency (IU), identity, and biological activity. For glycoprotein hormones like hCG, potency in International Units is the critical quality parameter — not simply chemical purity. Each lot ships with a QR-accessible COA. Review before use to confirm potency meets your assay requirements.

Additional information

Dosage

10000 IU, 2000 IU, 5000 IU

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