HMG

HMG

$84.99

HMG 75 IU

What is HMGX

HMG (75 IU) is supplied strictly for laboratory research and analytical applications, commonly referenced in endocrine axis, organ-signaling, and regulatory pathway studies.

Specifications:
  • Strength: 75 IU per vial
  • Format: Lyophilized powder
  • Category: Cellular & Regulatory Signaling
  • Documentation: COA available

Research Use Only — Not for Human Consumption.

1000 in stock

SKU: VE-HMGX-075 Category:

Description

  • About HMG

    Human Menopausal Gonadotropin (hMG, CAS 9002-68-0) is a purified glycoprotein mixture derived from the urine of postmenopausal women, containing both FSH (follicle-stimulating hormone) and LH (luteinizing hormone) activity in approximately equal proportions (typically 75 IU FSH + 75 IU LH per vial). It is supplied as a laboratory-grade lyophilized preparation intended strictly for analytical and non-clinical research applications.

    HMG is the primary dual FSH/LH receptor agonist tool compound for studying coordinated gonadotropin signaling in reproductive biology research. FSH acts on FSHR (a Gs-coupled GPCR on granulosa and Sertoli cells), while LH activity (via hCG-like β-subunit homology) engages LHCGR. The simultaneous activation of both receptors makes hMG the reference standard for follicular development pathway research, granulosa-theca cell co-signaling models, and Sertoli-Leydig axis studies. Researchers use hMG in KGN granulosa, TM3 Leydig, and primary follicular cell models to examine coordinated gonadotropin axis signaling, aromatase (CYP19A1) pathway activation, and folliculogenesis-related gene expression.

    COMMON RESEARCH APPLICATIONS

    Coordinated FSH/LH Dual-Receptor Signaling Research
    Dual FSHR + LHCGR agonist used in granulosa-theca co-culture and primary follicular cell models to study coordinated gonadotropin axis signaling, folliculogenesis pathway gene expression (FSHβ, LHR, aromatase CYP19A1), and steroid hormone biosynthesis.

    Follicular Development & Aromatase Pathway Studies
    Used in KGN granulosa and primary theca cell models under co-stimulation conditions to study aromatase (CYP19A1) induction, estradiol synthesis, and follicle-stimulating factor downstream target mapping in the ovarian signaling axis.

    Sertoli-Leydig Axis Signaling
    Dual gonadotropin reference in TM3 Leydig and TM4 Sertoli co-culture models to study testosterone/inhibin B co-production, FSH-driven Sertoli cell proliferation (GDNF, SCF expression), and androgen biosynthesis pathway mapping under physiological gonadotropin ratio conditions.

    Comparative Gonadotropin Preparation Benchmarking
    Reference standard for comparing FSH/LH co-stimulation effects vs. purified rFSH or rLH alone; used in dose-response matrix experiments to characterize synergistic vs. additive receptor co-activation in reproductive biology research.

  • Chemical Identity

    Compound Name: HMG

    Internal Catalog Code: HMG

    CAS Number: 9002-68-0

    Molecular Formula: Glycoprotein mixture

    Molecular Weight: N/A

    Physical Properties

    Form/Appearance: Lyophilized powder

    Quality & Testing

    Purity: As listed on lot-specific COA

    Testing Method : HPLC (as applicable) · identity confirmation per COA

    Verification

    COA: Lot-specific, included with order (QR on label)

    Handling & Storage

    Storage Temperature: Store desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.

    Light Sensitivity: Protect from light

    Moisture: Store desiccated when applicable

    Available Strengths: 75 mg

    SKU (75 mg): VE-HMGX-075

    • What is this product?
      HMG (human menopausal gonadotropin, CAS 9002-68-0) is supplied as a lyophilized glycoprotein mixture containing FSH + LH activity (~75 IU each per standard vial) for laboratory research use only. It is the reference dual-gonadotropin agonist in reproductive axis research. Available as VE-HMGX-075 (75 IU).
    • What purity and testing methods are used?
      Each lot is characterized for FSH and LH biological activity (IU potency by immunoassay). A lot-specific COA documenting both FSH and LH potency, identity, and preparation method is included with every order, accessible via QR code on the label.
    • What are the key chemical identifiers?
      CAS 9002-68-0 · Glycoprotein mixture (FSH + LH) · MW: N/A (glycoprotein complex) · Synonyms: human menopausal gonadotropin, menotropin, Pergonal, combined gonadotropin preparation.
    • How is HMG reconstituted for research use?
      Reconstitute with sterile water at the volume specified on the vial label to achieve the target IU/mL concentration. Use immediately or store reconstituted material at 4°C for up to 24 hours. For extended storage, add 0.1% BSA and aliquot at −20°C. Avoid repeated freeze-thaw.
    • What is the recommended storage upon receipt?
      Store lyophilized at −20°C desiccated. Short-term at 2–8°C acceptable. Inspect vials for integrity and review COA potency values upon receipt.
    • What is a COA and why does it matter?
      A COA documents lot-specific FSH and LH potency (IU), identity, and preparation source. For hMG, both FSH and LH activity values must be verified — the ratio affects experimental results. Each lot ships with a QR-accessible COA. Review before use to confirm both potency values meet your assay requirements.

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