Tesamoreline

Tesamoreline

Price range: $80.00 through $316.00

Tesamoreline 5mg / 10mg / 20mg

What is TESA

Tesamorelin is supplied strictly for laboratory research and analytical applications, commonly referenced in cellular repair, tissue-model, and recovery pathway studies.

Specifications:
  • Format: Lyophilized powder
  • Category: Muscle Growth & Recovery
  • Documentation: COA available

Research Use Only — Not for Human Consumption.

SKU: N/A Category:

Description

  • About Tesamorelin (GHRH analog / Egrifta® active ingredient)

    Tesamorelin — TH9507 (CAS 218949-48-5) — is a synthetic growth hormone-releasing hormone (GHRH) analog consisting of the full 44-amino acid sequence of endogenous GHRH conjugated to a trans-3-hexenoic acid group at the N-terminus, which confers enhanced stability against dipeptidyl peptidase IV (DPP-IV) degradation. As an FDA-approved GHRH analog (Egrifta®), tesamorelin stimulates pituitary somatotroph cells via the GHRH receptor (GHRHR) to increase endogenous GH pulsatility with less supra-physiological GH elevation than direct GH administration.

    This makes it a pharmacologically distinct tool from direct GH and from GHRPs (ipamorelin, GHRP-2) for dissecting pituitary GHRHR signaling. Supplied as lyophilized peptide for non-clinical research use only.

    COMMON RESEARCH APPLICATIONS

    GHRH Receptor Signaling
    Activates GHRHR on pituitary somatotrophs via Gs/cAMP/PKA pathway, increasing somatotroph proliferation and GH synthesis. Used in GH3 pituitary cell models to characterize GHRHR activation kinetics, receptor desensitization, and GH secretion dose-response.

    Comparative GHRH vs GHRP Signaling
    Tool compound for distinguishing GHRHR-mediated GH release from GHSR-1a (ghrelin receptor) GH release. Used alongside ipamorelin and CJC-1295 to study receptor-specific contributions to pulsatile GH secretion and IGF-1 downstream signaling.

    Metabolic Body Composition Studies
    Used in preclinical models examining visceral adipose tissue reduction, lipid metabolism (hepatic triglyceride, FFA flux), and insulin sensitivity as downstream effects of GH/IGF-1 axis stimulation in adipocyte and hepatocyte model systems.

    DPP-IV Stability Research
    The N-terminal trans-3-hexenoic acid modification prevents DPP-IV cleavage at position 2 (Ala→modified). Used in stability studies comparing tesamorelin vs. native GHRH and CJC-1295 (DAC) for DPP-IV resistance in plasma matrix experiments.

  • Chemical Identity

    Compound Name: Tesamorelin

    Synonyms: Egrifta active ingredient · TH9507 · trans-3-hexenoic acid GHRH(1-44) · GHRH analog tesamorelin

    CAS Number: 218949-48-5

    EC Number: N/A (synthetic peptide)

    Molecular Formula: C₂₂₁H₃₆₈N₆₈O₆₅S

    Molecular Weight: 5135.77 g/mol

    Physical Properties

    Appearance: White to off-white lyophilized powder

    Solubility (water): ~1 mg/mL in sterile water (pH 6–7)

    Solubility (organic): Limited; DMSO (~1–2 mg/mL)

    Hygroscopic: Yes — store desiccated

    Quality & Testing

    Purity: ≥98% (HPLC)

    Testing Method : Reverse-phase HPLC · MS confirmation · sequence verification

    Verification

    COA: Lot-specific, included with order (QR on label)

    SDS Supplier : See SDS/MSDS · OSHA HCS / GHS compliant

    Handling & Storage

    Storage Temperature: Store desiccated at −20°C long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.

    Light Sensitivity: Protect from light

    Reconstitution: Dissolve in sterile water (pH 6–7) at ~1 mg/mL; aliquot and store at −80°C

    Available Strengths: 5 mg · 10 mg · 20 mg

    SKU (5 mg): VE-TESA-005

    SKU (10 mg): VE-TESA-010

    SKU (20 mg): VE-TESA-020

    • What is this product?
      Tesamorelin (TH9507) is supplied as a lyophilized GHRH analog peptide (CAS 218949-48-5, MW 5135.77 g/mol) for laboratory research use only. It is the active ingredient in Egrifta® (FDA-approved) and stimulates pituitary GHRHR to increase endogenous GH pulsatility.
    • What purity and testing methods are used?
      Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity with sequence verification. A lot-specific COA is included with every order, accessible via QR code on the label.
    • What are the key chemical identifiers?
      CAS 218949-48-5 · Molecular formula C₂₂₁H₃₆₈N₆₈O₆₅S · MW 5135.77 g/mol · Synonyms: TH9507, Egrifta active ingredient, trans-3-hexenoic acid-GHRH(1-44).
    • How does tesamorelin differ from CJC-1295 and sermorelin?
      Sermorelin is a truncated GHRH(1-29); tesamorelin is the full GHRH(1-44) with N-terminal modification for DPP-IV stability. CJC-1295 (DAC) additionally conjugates to albumin for extended half-life (~8 days). Tesamorelin is preferred when studying authentic GHRH(1-44) biology with improved stability but without albumin binding.
    • How is tesamorelin reconstituted for research use?
      Dissolve in sterile water (pH 6–7) at ~1 mg/mL. Aliquot and store at −80°C for long-term stability. Avoid alkaline pH. Protect from light. Avoid repeated freeze-thaw cycles.
    • What is the recommended storage upon receipt?
      Store immediately at −20°C desiccated. For long-term stability, aliquot and store at −80°C. Short-term at 2–8°C acceptable. Inspect vials for integrity upon receipt.
    • What is a COA and why does it matter?
      A COA documents lot-specific purity (HPLC ≥98%), sequence verification (MS), and appearance. Each tesamorelin lot ships with a QR-accessible COA. Review before use to confirm identity and purity.

Additional information

Dosage

10mg, 20mg, 5mg

Reviews

There are no reviews yet.

Be the first to review “Tesamoreline”

Your email address will not be published. Required fields are marked *

Related products