Description
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About Gonadorelin Acetate
Gonadorelin Acetate — the acetate salt of synthetic GnRH (gonadotropin-releasing hormone, CAS 34973-08-5) — is a decapeptide that faithfully replicates the sequence of endogenous hypothalamic GnRH (Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂). It is supplied as a laboratory-grade lyophilized powder intended strictly for analytical and non-clinical research applications.
Gonadorelin binds the GnRH receptor (GnRHR, a Gq/11-coupled GPCR) on anterior pituitary gonadotroph cells, triggering PKC-mediated signaling cascades that drive luteinizing hormone (LH) and follicle-stimulating hormone (FSH) synthesis and pulsatile release. As the authentic GnRH decapeptide sequence without structural modification, it serves as the gold-standard tool compound for GnRH receptor pharmacology studies and is the reference against which GnRH analogs (leuprolide, buserelin, degarelix) are benchmarked. Researchers use gonadorelin in pituitary gonadotroph cell lines (LβT2, αT3-1), primary pituitary cultures, and hypothalamic-pituitary axis models to study GnRHR signaling kinetics, receptor internalization, FSH/LH pulse dynamics, and downstream steroidogenesis pathway mapping.
COMMON RESEARCH APPLICATIONS
GnRH Receptor Pharmacology
Reference ligand for GnRHR (Gq/11-coupled GPCR) activation studies in LβT2 and αT3-1 pituitary gonadotroph cell lines. Used in IP₁ accumulation, PKC activation, and receptor internalization assays to characterize native GnRH pulse kinetics vs. long-acting analogs.LH/FSH Secretion & Pulse Dynamics Research
Used in primary pituitary gonadotroph cultures and LβT2 cells to study pulse-dependent LH and FSH synthesis, c-Fos/Egr-1 transcription factor activation, and gonadotropin subunit (LHβ, FSHβ, CGα) gene expression under pulsatile vs. continuous stimulation.Hypothalamic-Pituitary Axis (HPA/HPG) Signaling
Tool compound for studying downstream HPG axis signaling in hypothalamic-pituitary co-culture systems; used to map GnRHR-to-gonadotropin cascade kinetics and receptor desensitization/resensitization dynamics.GnRH Analog Comparative Pharmacology
Authentic native sequence reference for benchmarking GnRH agonists (leuprolide, buserelin, histrelin) and antagonists (degarelix, cetrorelix) in receptor binding competition assays, potency comparisons, and receptor occupancy kinetics studies. -
Chemical Identity
Compound Name: Gonadorelin Acetate
Internal Catalog Code: Gonadorelin Acetate
CAS Number: 34973-08-5
Molecular Formula: C55H75N17O13 • xC2H4O2
Molecular Weight: 1182.29 g/mol
Physical Properties
Form/Appearance: Lyophilized powder
Quality & Testing
Purity: As listed on lot-specific COA
Testing Method : HPLC (as applicable) · identity confirmation per COA
Verification
COA: Lot-specific, included with order (QR on label)
Handling & Storage
Storage Temperature: Store desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.
Light Sensitivity: Protect from light
Moisture: Store desiccated when applicable
Available Strengths: 2 mg
SKU (2 mg): VE-GONA-002
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What is this product?
Gonadorelin Acetate (synthetic GnRH, CAS 34973-08-5, MW 1182.29 g/mol) is supplied as a lyophilized decapeptide for laboratory research use only. It is the authentic GnRH sequence used as a reference compound in GnRH receptor pharmacology and hypothalamic-pituitary axis research. Available as VE-GONA-002 (2 mg).
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What purity and testing methods are used?
Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity with sequence verification. A lot-specific COA is included with every order, accessible via QR code on the label.
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What are the key chemical identifiers?
CAS 34973-08-5 · Molecular formula C₅₅H₇₅N₁₇O₁₃ · xC₂H₄O₂ (acetate salt) · MW 1182.29 g/mol · Sequence: Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂ · Synonyms: GnRH, LHRH, luteinizing hormone-releasing hormone, synthetic gonadorelin.
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How does gonadorelin differ from GnRH analogs like leuprolide or buserelin in research use?
Gonadorelin is the unmodified native GnRH decapeptide — it has a short half-life (~2–4 min) and produces physiological pulsatile GnRH receptor stimulation. Analogs like leuprolide (D-Leu⁶, des-Gly¹⁰-Pro⁹-ethylamide modification) are used for continuous/downregulatory GnRHR studies. Gonadorelin is the reference standard for characterizing native receptor kinetics, pulse dynamics, and agonist benchmarking.
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How is Gonadorelin Acetate reconstituted for research use?
Dissolve in sterile water or PBS (pH 7.0) at ~1 mg/mL. Use immediately — gonadorelin degrades rapidly at room temperature. Aliquot and store at −80°C. Avoid repeated freeze-thaw cycles. Protect from light.
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What is the recommended storage upon receipt?
Store immediately at −20°C desiccated. Short-term at 2–8°C acceptable for active experimental periods (up to 1 week). Inspect vials for integrity upon receipt.
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What is a COA and why does it matter?
A COA documents lot-specific purity (HPLC ≥98%), sequence verification (MS: GnRH decapeptide confirmed), and appearance. Each gonadorelin lot ships with a QR-accessible COA. Review before use — purity is especially critical when using as a receptor agonist reference standard.
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