Chonluten

Chonluten

$102.00

Chonluten

What is CHON

Chonluten (20 mg) is supplied strictly for laboratory research and analytical applications, commonly referenced in cellular aging, regeneration, and redox pathway studies.

Specifications:
  • Strength: 20mg per vial
  • Format: Lyophilized powder
  • Category: Anti-Aging & Healing
  • Documentation: COA available

Research Use Only — Not for Human Consumption.

SKU: VE-CHON-020 Category:

Description

  • About Chonluten

    Chonluten — a synthetic Glu-Asp-Leu tripeptide (CAS 135558-10-0) from the Khavinson peptide bioregulator series — is a tissue-specific peptide studied as a model bronchial and colon epithelial cytoprotective signal in mucosal and connective tissue research. It is supplied as a laboratory-grade lyophilized powder intended strictly for analytical and non-clinical research applications.

    As a shorter member of the Khavinson short peptide bioregulator family, Chonluten is investigated for its putative selectivity toward bronchial and colon epithelial tissue signalling models. Researchers use Chonluten in Caco-2 intestinal epithelial, BEAS-2B bronchial epithelial, and primary colon organoid models to examine effects on mucosal barrier integrity (tight junction protein expression), inflammatory cytokine pathway modulation (NF-κB, COX-2), and cellular proliferation and apoptosis balance under standardised in vitro and ex vivo challenge conditions.

    COMMON RESEARCH APPLICATIONS

    Mucosal Barrier Integrity Research
    Chonluten is examined in Caco-2 and organoid models to study tight junction protein expression (ZO-1, occludin, claudin-1), transepithelial electrical resistance (TEER), and barrier permeability under cytokine or detergent challenge conditions.

    Intestinal & Bronchial Inflammation Pathway Screening
    Used in LPS-, IL-1β-, and TNF-α-challenged colon epithelial and bronchial cell models to study NF-κB activation, COX-2 expression, and pro-inflammatory cytokine (IL-6, IL-8) secretion as downstream inflammation pathway markers.

    Epithelial Proliferation & Apoptosis Assays
    Examined in BrdU/Ki-67 proliferation assays and caspase-3/7 apoptosis assays in bronchial and colon epithelial models to characterise Chonluten effects on epithelial renewal and cytoprotective signalling balance.

    Comparative Khavinson Mucosal Peptide Screening
    Benchmarked alongside Bronchogen, Cardiogen, and other Khavinson tetrapeptides to characterise tissue selectivity profiles and overlapping vs. distinct signalling features across mucosal and connective tissue models.

  • Chemical Identity

    Compound Name: Chonluten

    Synonyms: Glu-Asp-Leu · Khavinson bronchial/colon tripeptide · connective tissue cytoprotective peptide

    CAS Number: 135558-10-0

    EC Number: N/A (synthetic tripeptide)

    Molecular Formula: C12H22N4O6 (as free base; note: some sources reference slightly variable MW due to counterion)

    Molecular Weight: 306.33 g/mol

    Physical Properties

    Appearance: White to off-white lyophilized powder

    Solubility (water): ~5 mg/mL in sterile water or PBS (pH 7.0)

    Solubility (organic): Limited solubility in organic solvents

    Hygroscopic: Yes — store desiccated

    Quality & Testing

    Purity: ≥98% (HPLC)

    Testing Method : Reverse-phase HPLC · MS confirmation · sequence verification

    Verification

    COA: Lot-specific, included with order (QR on label)

    SDS Supplier : Velox Research Chemicals

    SDS Revision: Current lot · OSHA HCS / GHS compliant

    Handling & Storage

    Storage Temperature: Store desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.

    Light Sensitivity: Protect from light

    Reconstitution: Dissolve in sterile water or PBS (pH 7.0); use immediately or aliquot and store at −80°C

    Available Strengths: 20 mg

    SKU (20 mg): VE-CHON-020

    • What is this product?
      Chonluten (CAS 135558-10-0, MW 306.33 g/mol) is a synthetic Glu-Asp-Leu tripeptide from the Khavinson bioregulator series, supplied as a lyophilized powder for laboratory research use only. It is studied as a model mucosal cytoprotective peptide in bronchial and intestinal epithelial signalling research.
    • What purity and testing methods are used?
      Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity with sequence verification. A lot-specific COA is included with every order, accessible via QR code on the label.
    • What are the key chemical identifiers?
      CAS 135558-10-0 · Molecular formula C₁₂H₂₂N₄O₆ · MW 306.33 g/mol · Sequence: Glu-Asp-Leu · Synonyms: Khavinson bronchial/colon tripeptide.
    • What signaling pathways does Chonluten address in research models?
      Chonluten is studied in mucosal epithelial models for barrier integrity (ZO-1, TEER), NF-κB-mediated inflammation pathway research (IL-6, IL-8, COX-2 expression), and epithelial proliferation/apoptosis balance assays in Caco-2 intestinal and BEAS-2B bronchial epithelial cell lines.
    • How is Chonluten reconstituted for research use?
      Dissolve in sterile water or PBS (pH 7.0) at ~5 mg/mL. Use immediately or aliquot and store at −80°C. Avoid repeated freeze-thaw cycles. Protect from light.
    • What is the recommended storage upon receipt?
      Store immediately at −20°C desiccated. Short-term at 2–8°C is acceptable for up to 2 weeks. Inspect vials for integrity upon receipt.
    • What is a COA and why does it matter?
      A COA documents lot-specific purity (HPLC ≥98%), sequence verification (MS), and appearance. Each lot ships with a QR-accessible COA. Review before use to confirm identity and purity meet your experimental requirements.

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