Description
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About N-Acetyl Epitalon Amidate
N-Acetyl Epitalon Amidate is a doubly-stabilized synthetic derivative of Epitalon (Ala-Glu-Asp-Gly, the tetrapeptide analog of Epithalamin), incorporating both N-terminal acetylation and C-terminal amidation for enhanced resistance to peptidase degradation and improved metabolic stability. It is supplied as a laboratory-grade lyophilized powder intended strictly for analytical and non-clinical research applications.
Epitalon (the parent compound) was developed by Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology as a synthetic analog of the pineal gland peptide Epithalamin, and is the most widely studied peptide in the area of telomerase activation and cellular aging research in the Khavinson series. The acetyl-amidate modification strategy mirrors that applied to Selank and Semax to extend peptide half-life without altering the core sequence bioactivity. Researchers use N-Acetyl Epitalon Amidate in primary fibroblast, HeLa, and human embryonic cell models to study telomerase activation (hTERT expression), telomere length maintenance pathway mapping, circadian gene regulation (CLOCK/BMAL1/PER2), and cellular senescence pathway markers (p16, p21, SA-β-gal) under standardized in vitro conditions.
COMMON RESEARCH APPLICATIONS
Telomerase Activation & Telomere Biology Research
N-Acetyl Epitalon Amidate is examined in primary fibroblast, HeLa, and WI-38 models to study hTERT expression upregulation, TERT/TERC complex activity, and telomere length maintenance pathway mapping as markers of cellular aging and replicative senescence.Circadian Gene Regulation Studies
Used in synchronized cell models and pinealocyte cultures to characterize CLOCK/BMAL1/PER2/CRY1 expression changes and melatonin synthesis pathway markers (AANAT/HIOMT activity) as readouts of pineal-axis circadian biology pathway modulation.Cellular Senescence & Aging Biomarker Assays
Examined in serial-passaged human diploid fibroblast and BJ cell models to study effects on p16/p21 cyclin-dependent kinase inhibitor expression, SA-β-gal activity, and SASP cytokine secretion as cellular aging endpoint markers.Stability-Enhanced Epitalon Comparative Studies
Used as the extended-half-life reference in paired studies vs. unmodified Epitalon (Ala-Glu-Asp-Gly) to characterize the pharmacokinetic contribution of dual N-acetyl/C-amide terminal protection on peptide stability, cellular uptake, and telomerase pathway response magnitude. -
Chemical Identity
Compound Name: N-Acetyl Epitalon Amidate
Internal Catalog Code: N-Acetyl Epitalon Amidate
CAS Number: N/A
Molecular Formula: C18H27N5O8
Molecular Weight: 457.44 g/mol
Physical Properties
Form/Appearance: Lyophilized powder
Quality & Testing
Purity: As listed on lot-specific COA
Testing Method : HPLC (as applicable) · identity confirmation per COA
Verification
COA: Lot-specific, included with order (QR on label)
Handling & Storage
Storage Temperature: Store desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.
Light Sensitivity: Protect from light
Moisture: Store desiccated when applicable
Available Strengths: 5 mg
SKU (5 mg): VE-NACE-005
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What is this product?
N-Acetyl Epitalon Amidate (MW 457.44 g/mol, C₁₈H₂₇N₅O₈) is a doubly-stabilized synthetic derivative of Epitalon (Ala-Glu-Asp-Gly), supplied as a lyophilized powder for laboratory research use only. It is studied in telomerase activation and cellular aging research. Available as VE-NACE-005 (5 mg).
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What purity and testing methods are used?
Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity with sequence and modification verification (N-Ac and C-amide confirmed). A lot-specific COA is included with every order, accessible via QR code on the label.
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What are the key chemical identifiers?
No registered CAS number · Molecular formula C₁₈H₂₇N₅O₈ · MW 457.44 g/mol · Sequence: Ac-Ala-Glu-Asp-Gly-NH₂ · Synonyms: N-Ac-Epitalon-NH₂, acetylated amidated Epitalon, stabilized Epithalamin synthetic analog.
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How is N-Acetyl Epitalon Amidate reconstituted for research use?
Dissolve in sterile water or PBS (pH 7.0) at ~1 mg/mL. Use immediately or aliquot and store at −80°C. Avoid repeated freeze-thaw cycles. Protect from light and moisture.
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What is the recommended storage upon receipt?
Store immediately at −20°C desiccated. Short-term at 2–8°C acceptable for up to 2 weeks. Inspect vials for integrity upon receipt.
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What is a COA and why does it matter?
A COA documents lot-specific purity (HPLC ≥98%), MS identity, and modification verification (N-acetyl and C-amide confirmed). For modified peptides, confirming terminal group integrity is essential — incomplete modification produces a mixture of forms. Each lot ships with a QR-accessible COA. Review before use.
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What is this product?
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