Vesugen

Vesugen

$99.99

Vesugen 20 mg

What is VESU

Vesugen (20 mg) is supplied strictly for laboratory research and analytical applications, commonly referenced in cellular aging, regeneration, and redox pathway studies.

Specifications:
  • Strength: 20 mg per vial
  • Format: Lyophilized powder
  • Category: Anti-Aging & Healing
  • Documentation: COA available

Research Use Only — Not for Human Consumption.

1000 in stock

SKU: VE-VESU-020 Category:

Description

  • About Vesugen

    Vesugen — a synthetic Lys-Glu-Asp-Ala tetrapeptide (CAS 135537-16-5) from the Khavinson peptide bioregulator series — is a tissue-specific peptide studied as a model vascular endothelial and blood vessel cytoprotective signal in vascular biology and angiogenesis research. It is supplied as a laboratory-grade lyophilized powder intended strictly for analytical and non-clinical research applications.

    As a member of the short peptide bioregulator family developed at the St. Petersburg Institute of Bioregulation and Gerontology, Vesugen is investigated for its selectivity toward vascular endothelial cell and smooth muscle cell signaling models. Researchers use Vesugen in HUVEC, HAEC, and HVSMC (human vascular smooth muscle cell) models to examine effects on endothelial cell proliferation and migration (VEGF/VEGFR2 pathway activation), eNOS/NO signaling and vascular tone markers, ICAM-1/VCAM-1 inflammatory adhesion molecule expression, oxidative stress response in endothelium (Nrf2/HO-1/eNOS axis), and senescence-associated secretory phenotype (SASP) markers under standardized in vitro conditions.

    COMMON RESEARCH APPLICATIONS

    Endothelial Cell Signaling & eNOS Pathway Research
    Vesugen is examined in HUVEC and HAEC models to study VEGFR2/PI3K/Akt/eNOS pathway activation, nitric oxide (NO) production (Griess assay, DAF-FM fluorescence), and endothelial proliferation as vascular function endpoint markers.

    Vascular Inflammation & Adhesion Molecule Expression
    Used in TNF-α and IL-1β cytokine-challenged HUVEC models to characterize ICAM-1, VCAM-1, and E-selectin expression, NF-κB pathway modulation, and monocyte adhesion as endothelial inflammatory pathway endpoint markers.

    Endothelial Senescence & Aging Vascular Biology
    Examined in serial-passaged HUVEC models to study p21/p53/SA-β-gal senescence markers, SASP cytokine secretion (IL-6, IL-8, MMP-3), and Nrf2/HO-1 antioxidant pathway activation as vascular aging endpoint characterization tools.

    Comparative Khavinson Vascular Peptide Screening
    Benchmarked alongside related Khavinson tetrapeptides (Livagen, Cardiogen) to characterize tissue-selective vascular endothelial vs. cardiac signaling profiles and shared vs. distinct features within the vascular-targeted short peptide bioregulator class.

  • Chemical Identity

    Compound Name: Vesugen

    Internal Catalog Code: Vesugen

    CAS Number: 135537-16-5

    Molecular Formula: C18H33N5O7

    Molecular Weight: 435.48 g/mol

    Physical Properties

    Form/Appearance: Lyophilized powder

    Quality & Testing

    Purity: As listed on lot-specific COA

    Testing Method : HPLC (as applicable) · identity confirmation per COA

    Verification

    COA: Lot-specific, included with order (QR on label)

    Handling & Storage

    Storage Temperature: Store desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.

    Light Sensitivity: Protect from light

    Moisture: Store desiccated when applicable

    Available Strengths: 20 mg

    SKU (20 mg): VE-VESU-020

    • What is this product?
      Vesugen (CAS 135537-16-5, MW 435.48 g/mol, C₁₈H₃₃N₅O₇) is a synthetic Lys-Glu-Asp-Ala tetrapeptide from the Khavinson bioregulator series, supplied as a lyophilized powder for laboratory research use only. It is studied as a model vascular endothelial cytoprotective peptide. Available as VE-VESU-020 (20 mg).
    • What purity and testing methods are used?
      Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity with sequence verification. A lot-specific COA is included with every order, accessible via QR code on the label.
    • What are the key chemical identifiers?
      CAS 135537-16-5 · Molecular formula C₁₈H₃₃N₅O₇ · MW 435.48 g/mol · Sequence: Lys-Glu-Asp-Ala · Synonyms: KEDA, Khavinson vascular peptide, vascular endothelial cytoprotective tetrapeptide.
    • What signaling pathways does Vesugen address in research models?
      Vesugen is studied in endothelial and vascular cell models for: VEGF/VEGFR2/eNOS pathway activation and NO production, ICAM-1/VCAM-1/E-selectin expression under cytokine challenge (TNF-α, IL-1β), Nrf2/HO-1/NQO1 antioxidant pathway in endothelium, PI3K/Akt/mTOR endothelial survival signaling, and senescence markers (p21/p53/SA-β-gal) under oxidative stress and serial passaging models.
    • How is Vesugen reconstituted for research use?
      Dissolve in sterile water or PBS (pH 7.0) at ~5 mg/mL. Use immediately or aliquot and store at −80°C. Avoid repeated freeze-thaw cycles. Protect from light.
    • What is the recommended storage upon receipt?
      Store immediately at −20°C desiccated. Short-term at 2–8°C acceptable for up to 2 weeks. Inspect vials for integrity upon receipt.
    • What is a COA and why does it matter?
      A COA documents lot-specific purity (HPLC ≥98%), sequence verification (MS: Lys-Glu-Asp-Ala confirmed), and appearance. Each Vesugen lot ships with a QR-accessible COA. Review before use to confirm identity and purity meet your experimental requirements.

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