Testagen

Testagen

$99.99

Testagen 20 mg

What is TEST

Testagen (20 mg) is supplied strictly for laboratory research and analytical applications, commonly referenced in endocrine axis, organ-signaling, and regulatory pathway studies.

Specifications:
  • Strength: 20 mg per vial
  • Format: Lyophilized powder
  • Category: Cellular & Regulatory Signaling
  • Documentation: COA available

Research Use Only — Not for Human Consumption.

1000 in stock

SKU: VE-TEST-020 Category:

Description

  • About Testagen

    Testagen — a synthetic Lys-Glu-Asp-Gly tetrapeptide (CAS 135537-15-4) from the Khavinson peptide bioregulator series — is a tissue-specific peptide studied as a model testicular and gonadal cytoprotective signal in male reproductive biology and Leydig cell research. It is supplied as a laboratory-grade lyophilized powder intended strictly for analytical and non-clinical research applications.

    As a member of the short peptide bioregulator family developed at the St. Petersburg Institute of Bioregulation and Gerontology, Testagen is investigated for its selectivity toward testicular Leydig cell and spermatogenic cell signaling models. Researchers use Testagen in TM3 Leydig, MA-10, and primary testicular cell models to examine effects on testosterone biosynthesis pathway markers (StAR, CYP11A1, 3β-HSD, 17β-HSD expression), LHCGR/cAMP/PKA signaling cascade modulation, oxidative stress response in gonadal tissue (Nrf2/SOD1), and spermatogenic cell survival and apoptosis markers under standardized in vitro conditions.

    COMMON RESEARCH APPLICATIONS

    Leydig Cell Steroidogenesis Pathway Research
    Testagen is examined in TM3 Leydig, MA-10, and primary Leydig cell models to study StAR protein expression, CYP11A1/CYP17A1/3β-HSD/17β-HSD steroidogenic enzyme induction, and testosterone biosynthesis pathway kinetics under LHCGR challenge conditions.

    Oxidative Stress Protection in Gonadal Cells
    Used in primary testicular cell and TM3 models under H₂O₂ and heat stress (37°C vs. 43°C) challenge to characterize Nrf2/SOD1/catalase pathway activation, mitochondrial membrane potential (ΔΨm), and spermatogenic cell apoptosis (Bcl-2/Bax, caspase-3) endpoint markers.

    Spermatogenic Cell Survival & Proliferation Assays
    Examined in GC-1 (spermatogonia), GC-2 (spermatocyte), and primary testicular cell models to study proliferation (Ki-67, BrdU incorporation), DNA damage markers (γH2AX), and spermatogenic pathway gene expression under toxicant or aging-model stress conditions.

    Comparative Khavinson Gonadal Peptide Screening
    Benchmarked alongside related Khavinson tetrapeptides (Prostamax, Pancragen) to characterize tissue-selective endocrine and steroidogenic signaling profiles, and shared vs. distinct pathway features in the gonadal/endocrine short peptide bioregulator class.

  • Chemical Identity

    Compound Name: Testagen

    Internal Catalog Code: Testagen

    CAS Number: 135537-15-4

    Molecular Formula: C18H33N5O6

    Molecular Weight: 403.49 g/mol

    Physical Properties

    Form/Appearance: Lyophilized powder

    Quality & Testing

    Purity: As listed on lot-specific COA

    Testing Method : HPLC (as applicable) · identity confirmation per COA

    Verification

    COA: Lot-specific, included with order (QR on label)

    Handling & Storage

    Storage Temperature: Store desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.

    Light Sensitivity: Protect from light

    Moisture: Store desiccated when applicable

    Available Strengths: 20 mg

    SKU (20 mg): VE-TEST-020

    • What is this product?
      Testagen (CAS 135537-15-4, MW 403.49 g/mol, C₁₈H₃₃N₅O₆) is a synthetic Lys-Glu-Asp-Gly tetrapeptide from the Khavinson bioregulator series, supplied as a lyophilized powder for laboratory research use only. It is studied as a model testicular/Leydig cell cytoprotective peptide. Available as VE-TEST-020 (20 mg).
    • What purity and testing methods are used?
      Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity with sequence verification. A lot-specific COA is included with every order, accessible via QR code on the label.
    • What are the key chemical identifiers?
      CAS 135537-15-4 · Molecular formula C₁₈H₃₃N₅O₆ · MW 403.49 g/mol · Sequence: Lys-Glu-Asp-Gly · Synonyms: KEDG, Khavinson testicular peptide, gonadal cytoprotective tetrapeptide.
    • How is Testagen reconstituted for research use?
      Dissolve in sterile water or PBS (pH 7.0) at ~5 mg/mL. Use immediately or aliquot and store at −80°C. Avoid repeated freeze-thaw cycles. Protect from light.
    • What is the recommended storage upon receipt?
      Store immediately at −20°C desiccated. Short-term at 2–8°C acceptable for up to 2 weeks. Inspect vials for integrity upon receipt.
    • What is a COA and why does it matter?
      A COA documents lot-specific purity (HPLC ≥98%), sequence verification (MS: Lys-Glu-Asp-Gly confirmed), and appearance. Each Testagen lot ships with a QR-accessible COA. Review before use to confirm identity and purity meet your experimental requirements.

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