Pancragen

Pancragen

$99.99

Pancragen 20 mg

What is PANC

Pancragen (20 mg) is supplied strictly for laboratory research and analytical applications, commonly referenced in endocrine axis, organ-signaling, and regulatory pathway studies.

Specifications:
  • Strength: 20 mg per vial
  • Format: Lyophilized powder
  • Category: Cellular & Regulatory Signaling
  • Documentation: COA available

Research Use Only — Not for Human Consumption.

1000 in stock

SKU: VE-PANC-020 Category:

Description

  • About Pancragen

    Pancragen — a synthetic Lys-Glu-Asp-Glu tetrapeptide (CAS 135558-09-7) from the Khavinson peptide bioregulator series — is a tissue-specific peptide studied as a model pancreatic cytoprotective signal in islet biology and glucose metabolism research. It is supplied as a laboratory-grade lyophilized powder intended strictly for analytical and non-clinical research applications.

    As a member of the short peptide bioregulator family developed by the St. Petersburg Institute of Bioregulation and Gerontology, Pancragen is investigated for its selectivity toward pancreatic acinar and islet cell signaling models. Researchers use Pancragen in MIN6, INS-1 β-cell, AR42J pancreatic acinar, and primary islet culture models to examine effects on insulin secretion pathway regulators (PDX-1, Nkx6.1, MafA expression), glucokinase activity and glucose-sensing pathway markers, oxidative stress response in islet cells (Nrf2/SOD2), and pancreatic cell apoptosis and survival signaling under diabetogenic challenge conditions.

    COMMON RESEARCH APPLICATIONS

    Pancreatic β-Cell Identity & Transcription Factor Research
    Pancragen is examined in MIN6 and INS-1E β-cell models to study effects on PDX-1, Nkx6.1, and MafA transcription factor expression as β-cell identity and function markers under normoglycemic and glucolipotoxic challenge conditions.

    Glucose-Stimulated Insulin Secretion (GSIS) Studies
    Used in isolated primary islet and INS-1E models under sequential low/high glucose challenge to characterize insulin secretion kinetics, glucokinase (GCK) activity, GLUT2 expression, and mitochondrial fuel metabolism pathway responsiveness.

    β-Cell Oxidative Stress & Cytoprotection Assays
    Examined in streptozotocin (STZ) and cytokine-challenge (IL-1β/IFN-γ) β-cell injury models to study Nrf2/SOD2/catalase pathway activation, mitochondrial membrane potential (ΔΨm), and Bcl-2/Bax apoptosis balance as cytoprotective endpoint markers.

    Comparative Khavinson Endocrine Peptide Screening
    Benchmarked alongside Testagen (gonadal) and Prostamax (prostate) tetrapeptides to characterize tissue-selective endocrine signaling profiles and shared vs. distinct signaling features within the Khavinson short peptide bioregulator class.

  • Chemical Identity

    Compound Name: Pancragen

    Internal Catalog Code: Pancragen

    CAS Number: 135558-09-7

    Molecular Formula: C16H29N5O7

    Molecular Weight: 391.43 g/mol

    Physical Properties

    Form/Appearance: Lyophilized powder

    Quality & Testing

    Purity: As listed on lot-specific COA

    Testing Method : HPLC (as applicable) · identity confirmation per COA

    Verification

    COA: Lot-specific, included with order (QR on label)

    Handling & Storage

    Storage Temperature: Store desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.

    Light Sensitivity: Protect from light

    Moisture: Store desiccated when applicable

    Available Strengths: 20 mg

    SKU (20 mg): VE-PANC-020

    • What is this product?
      Pancragen (CAS 135558-09-7, MW 391.43 g/mol, C₁₆H₂₉N₅O₇) is a synthetic Lys-Glu-Asp-Glu tetrapeptide from the Khavinson bioregulator series, supplied as a lyophilized powder for laboratory research use only. It is studied as a model pancreatic cytoprotective peptide. Available as VE-PANC-020 (20 mg).
    • What purity and testing methods are used?
      Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity with sequence verification. A lot-specific COA is included with every order, accessible via QR code on the label
    • What are the key chemical identifiers?
      CAS 135558-09-7 · Molecular formula C₁₆H₂₉N₅O₇ · MW 391.43 g/mol · Sequence: Lys-Glu-Asp-Glu · Synonyms: KEDE, Khavinson pancreatic peptide, pancreatic cytoprotective tetrapeptide.
    • What signaling pathways does Pancragen address in research models?
      Pancragen is studied in β-cell and islet models for: PDX-1/Nkx6.1/MafA transcription factor expression (β-cell identity markers), glucokinase (GCK) activity and GLUT2 expression under glucose challenge, Nrf2/SOD2/catalase oxidative stress pathway in islets, and Bcl-2/Bax apoptosis balance under cytokine-induced diabetogenic stress.
    • How is Pancragen reconstituted for research use?
      Dissolve in sterile water or PBS (pH 7.0) at ~5 mg/mL. Use immediately or aliquot and store at −80°C. Avoid repeated freeze-thaw cycles. Protect from light.
    • What is the recommended storage upon receipt?
      Store immediately at −20°C desiccated. Short-term at 2–8°C acceptable for up to 2 weeks. Inspect vials for integrity upon receipt
    • What is a COA and why does it matter?
      A COA documents lot-specific purity (HPLC ≥98%), sequence verification (MS: Lys-Glu-Asp-Glu confirmed), and appearance. Each Pancragen lot ships with a QR-accessible COA. Review before use to confirm identity and purity meet your experimental requirements.

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