Description
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About Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro / anxiolytic nootropic heptapeptide)
Selank — Thr-Lys-Pro-Arg-Pro-Gly-Pro (TP-7, CAS 129954-34-3) — is a synthetic 7-amino acid heptapeptide developed by the Institute of Molecular Genetics of the Russian Academy of Sciences as a stable analog of the endogenous immunopeptide tuftsin (Thr-Lys-Pro-Arg). Tuftsin is a fragment of IgG that regulates phagocyte activity; Selank extends this sequence with Pro-Gly-Pro to enhance CNS stability and GABAergic activity.
It has been studied for effects on GABA-A receptor modulation, brain-derived neurotrophic factor (BDNF) expression, and enkephalin metabolism. Selank is resistant to rapid proteolytic degradation compared to tuftsin, making it a more stable pharmacological tool for neuropeptide signaling research. Supplied as lyophilized heptapeptide for non-clinical research use only.
COMMON RESEARCH APPLICATIONS
GABAergic Signaling Research
Selank has been studied for potentiation of GABA-A receptor activity in cortical neuron cultures. Used in patch-clamp electrophysiology and GABA-A ligand binding assays to characterize benzodiazepine-independent anxiolytic signaling pathways.BDNF Expression Studies
Modulates BDNF and NGF expression in cortical and hippocampal cell models. Used in qPCR and ELISA studies examining neurotrophin upregulation in stress-challenge paradigms alongside established BDNF modulators for pathway comparison.Enkephalin Metabolism & Neuropeptide Stability
Selank inhibits enkephalin-degrading enzymes (neprilysin, aminopeptidase N), prolonging endogenous opioid peptide half-life. Used in enzymatic stability assays and peptide degradation kinetics studies in brain homogenate matrices.Immune-Neural Crosstalk (Neuroimmunology)
As a tuftsin analog, studied for IL-6, TNF-α, and IFN-γ modulation in macrophage and T-cell models; used to examine the intersection of innate immune signaling and neuropeptide activity in co-culture systems. -
Chemical Identity
Compound Name: Selank
Synonyms: TP-7 · Selanк · threonyl-lysyl-prolyl-arginyl-prolyl-glycyl-proline · tuftsin fragment analog · TKPRPGP
CAS Number: 129954-34-3
EC Number: N/A (synthetic heptapeptide)
Molecular Formula: C₃₃H₅₇N₁₁O₉
Molecular Weight: 751.88 g/mol
Physical Properties
Appearance: White lyophilized powder
Solubility (water): ~5 mg/mL in sterile water or PBS (pH 7.0)
Solubility (organic): Limited; DMSO (~2 mg/mL)
Hygroscopic: Yes — store desiccated
Quality & Testing
Purity: ≥98% (HPLC)
Testing Method : Reverse-phase HPLC · MS confirmation
Verification
COA: Lot-specific, included with order (QR on label)
SDS Supplier : See SDS/MSDS · OSHA HCS / GHS compliant
Handling & Storage
Storage Temperature: Store desiccated at −20°C long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.
Light Sensitivity: Protect from light
Reconstitution: Dissolve in sterile water or PBS at ~5 mg/mL; aliquot and store at −20°C
Available Strengths: 5 mg · 10 mg
SKU (5 mg): VE-SELAN-005
SKU (10 mg): VE-SELAN-010
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What is this product?
Selank (TP-7) is supplied as a lyophilized synthetic heptapeptide (CAS 129954-34-3, MW 751.88 g/mol) for laboratory research use only. It is a stable analog of the endogenous immunopeptide tuftsin, developed for CNS neuropeptide and GABAergic signaling research.
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What purity and testing methods are used?
Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity. A lot-specific COA is included with every order, accessible via QR code on the label.
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What are the key chemical identifiers?
CAS 129954-34-3 · Molecular formula C₃₃H₅₇N₁₁O₉ · MW 751.88 g/mol · Synonyms: TP-7, TKPRPGP, threonyl-lysyl-prolyl-arginyl-prolyl-glycyl-proline, tuftsin fragment analog.
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How is Selank reconstituted for research use?
Dissolve in sterile water or PBS (pH 7.0) at ~5 mg/mL. Aliquot and store at −20°C. Avoid repeated freeze-thaw cycles. Protect from light.
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What is the recommended storage upon receipt?
Store immediately at −20°C desiccated. Short-term at 2–8°C acceptable for up to 2 weeks. Inspect vials for integrity upon receipt.
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What is a COA and why does it matter?
A COA documents lot-specific purity (HPLC ≥98%), identity (MS), and appearance. Each Selank lot ships with a QR-accessible COA. Review before use to confirm identity and purity.
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What is this product?
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