Liraglutide
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Liraglutide

Price range: $69.00 through $199.00

Liraglutide | GLP-1 Receptor Agonist Peptide

Metabolic & GLP-1 Signaling Research

Liraglutide is a synthetic GLP-1 receptor agonist peptide commonly referenced
in metabolic signaling studies, glucose regulation research, incretin pathway
analysis, and endocrine communication models.

In plain terms: Liraglutide is used in research to examine how specific hormone pathways control blood sugar levels and insulin responses in metabolic models.

  • Lyophilized research peptide
  • ≥98% purity by HPLC analysis
  • Lot-specific COA and laboratory documentation available

Research Use Only — Not for Human Consumption.

SKU: VE-LIRA Category:

Description

  • About Liraglutide

    Liraglutide — the active ingredient in Victoza® and Saxenda® (CAS 204656-20-2) — is a long-acting GLP-1 receptor agonist with a C16 fatty acid chain (palmitoyl) attached via a glutamic acid linker to Lys²⁶, enabling reversible albumin binding and an extended half-life of ~13 hours (versus ~2 minutes for native GLP-1). It is supplied as a laboratory-grade lyophilized powder intended strictly for analytical and non-clinical research applications.

    Unlike native GLP-1(7-37), liraglutide is resistant to DPP-4 degradation due to Arg³⁴Lys and Lys²⁶ modifications. It activates GLP-1R (a Gs-coupled GPCR) to stimulate glucose-dependent insulin secretion, suppress glucagon, and delay gastric emptying. As the first once-daily GLP-1 agonist approved for both T2DM and obesity, liraglutide has extensive characterization across pancreatic β-cell, hypothalamic appetite circuit, and hepatic metabolic signaling research. Researchers use liraglutide in MIN6, INS-1, and primary islet models for β-cell GLP-1R/cAMP/PKA signaling studies, and in hypothalamic neuronal models (N41 cells) for appetite circuit mapping comparative to semaglutide and other next-generation GLP-1RAs.

    COMMON RESEARCH APPLICATIONS

    GLP-1R Pharmacology & β-Cell Signaling
    Used in MIN6, INS-1E, and HEK293-GLP1R models to study GLP-1R agonist-driven cAMP/PKA/CREB pathway activation, glucose-stimulated insulin secretion (GSIS) augmentation, β-arrestin recruitment, and receptor desensitization under once-daily dosing simulation protocols.

    Incretin Axis & Glucagon Suppression Research
    Tool compound for studying GLP-1R-mediated glucagon suppression in α-cell (αTC1-6) models and insulin/glucagon co-secretion dynamics in isolated islet models; used to map incretin axis signaling under normoglycemic vs. hyperglycemic challenge conditions.

    Hypothalamic Appetite Circuit Research
    Used in N41, GT1-7, and primary hypothalamic neuron models to study GLP-1R-driven POMC/CART pathway activation, NPY/AgRP suppression, and appetite-regulatory neural signaling at the arcuate nucleus level.

    Comparative GLP-1R Agonist Benchmarking
    First-generation long-acting GLP-1RA reference standard for comparing receptor activation kinetics, cAMP response magnitude, and β-arrestin bias ratios against semaglutide (C18 diacid), dulaglutide (IgG fusion), and next-generation GLP-1RAs in head-to-head receptor pharmacology studies.

  • Chemical Identity

    Compound Name: Liraglutide

    Internal Catalog Code: Liraglutide

    CAS Number: 204656-20-2

    Molecular Formula: C172H265N43O51

    Molecular Weight: 3751.20 g/mol

    Physical Properties

    Form/Appearance: Lyophilized powder

    Quality & Testing

    Purity: As listed on lot-specific COA

    Testing Method : HPLC (as applicable) · identity confirmation per COA

    Verification

    COA: Lot-specific, included with order (QR on label)

    Handling & Storage

    Storage Temperature: Store desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.

    Light Sensitivity: Protect from light

    Moisture: Store desiccated when applicable

    Available Strengths: 5 mg · 10 mg · 30 mg

    SKU (5 mg): VE-LIRA-005

    SKU (10 mg): VE-LIRA-010

    SKU (30 mg): VE-LIRA-030

    • What is this product?
      Liraglutide (Victoza®/Saxenda® active ingredient, CAS 204656-20-2, MW 3751.20 g/mol, C₁₇₂H₂₆₅N₄₃O₅₁) is supplied as a lyophilized long-acting GLP-1 receptor agonist for laboratory research use only. Available as VE-LIRA-005 (5 mg), VE-LIRA-010 (10 mg), and VE-LIRA-030 (30 mg).
    • What purity and testing methods are used?
      Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity with sequence verification. A lot-specific COA is included with every order, accessible via QR code on the label.
    • What are the key chemical identifiers?
      CAS 204656-20-2 · Molecular formula C₁₇₂H₂₆₅N₄₃O₅₁ · MW 3751.20 g/mol · Synonyms: Victoza active ingredient, Saxenda API, NN2211, liraglutide GLP-1 analog.
    • How is liraglutide reconstituted for research use?
      Dissolve in sterile water or PBS (pH 7.4) at ~1 mg/mL. DMSO (~5 mg/mL) may be used for organic solvent applications. Avoid repeated freeze-thaw cycles. Store desiccated at −20°C long-term. Protect from light.
    • What is the recommended storage upon receipt?
      Store immediately at −20°C desiccated. Short-term 2–8°C acceptable. Avoid repeated freeze-thaw. Inspect vials for integrity upon receipt.
    • What is a COA and why does it matter?
      A COA documents lot-specific purity (HPLC ≥98%), identity (MS), and sequence verification. Each liraglutide lot ships with a QR-accessible COA. Review before use to confirm identity and purity meet your experimental requirements.

  • PubMed Literature Search — Liraglutide
    Primary literature · curated search
    Open PubMed

    PubChem Compound Record
    Full chemical data, bioassays, patents
    View Record

    Source Document / Insert
    Supplier insert or supporting SDS source
    Download PDF

Additional information

Dosage

10mg, 30mg, 5mg

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