S3M4
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S3M4

Price range: $30.00 through $40.00

S3M4 | GLP-1 Research Peptide

Metabolic & GLP-1 Signaling Research

S3M4 is a synthetic research peptide commonly referenced in metabolic signaling
studies, glucoregulatory pathway analysis, endocrine communication research,
and cellular energy regulation models.

In plain terms: S3M4 is used in lab models to analyze how insulin-triggering pathways react to hormone signals to control blood sugar.

  • Lyophilized research peptide
  • ≥98% purity by HPLC analysis
  • Lot-specific COA and laboratory documentation available

Research Use Only — Not for Human Consumption.

SKU: VE-S3M4 Category:

Description

  • About Semaglutide (Ozempic® active ingredient)

    Semaglutide — the active peptide in Ozempic® and Rybelsus® (CAS 910463-68-2) — is a long-acting GLP-1 receptor agonist with a C18 fatty diacid chain enabling albumin binding and extended half-life (~165 hours). It is one of the most widely studied incretin mimetics for GLP-1 receptor pharmacology research. Unlike native GLP-1, semaglutide is resistant to DPP-4 degradation due to Aib substitution at position 8, making it a uniquely stable tool compound for GLP-1R binding, cAMP/PKA signaling cascades, and receptor internalization studies in vitro and in preclinical models. Supplied as lyophilized peptide for analytical and non-clinical research applications only. Internal catalog code: VE-S3M4.

    COMMON RESEARCH APPLICATIONS

    GLP-1 Receptor Binding & Signaling
    Semaglutide activates GLP-1R with ~5-fold greater potency vs native GLP-1. Used to study cAMP/PKA pathway activation, β-arrestin recruitment, and receptor internalization kinetics in pancreatic β-cell lines (INS-1, MIN6) and HEK293-GLP1R models.

    Incretin Axis Research
    Tool compound for studying GLP-1R-driven insulin secretion, glucagon suppression, and gastric emptying delay in isolated islet and enteroendocrine cell models.

    Metabolic Pathway Studies
    Used in preclinical models examining hypothalamic appetite signaling, POMC neuron activation, and energy expenditure via GLP-1R in the CNS.

    Comparative GLP-1R Agonist Benchmarking
    Reference standard for comparing potency and receptor dynamics of novel GLP-1R agonists including tirzepatide dual agonists and retatrutide triple agonists.

  • Chemical Identity

    Compound Name: Semaglutide

    Synonyms: Ozempic active ingredient · Rybelsus API · NNC0113-0217 · semaglutide GLP-1 analog

    CAS Number: 910463-68-2

    EC Number: N/A (synthetic peptide)

    Molecular Formula: C₁₈₇H₂₉₁N₄₅O₅₉

    Molecular Weight: 4113.58 g/mol

    Internal Catalog Code: VE-S3M4

    Physical Properties

    Appearance: White to off-white lyophilized powder

    Solubility (water): ~1 mg/mL in sterile water or PBS (pH 7.4)

    Solubility (organic): Soluble in DMSO (~5 mg/mL); limited in ethanol

    Hygroscopic: Yes — store desiccated

    Quality & Testing

    Purity: ≥98% (HPLC)

    Testing Method : Reverse-phase HPLC · MS confirmation · sequence verification

    Verification

    COA: Lot-specific, included with order (QR on label)

    SDS Supplier : See SDS/MSDS · OSHA HCS / GHS compliant

    Handling & Storage

    Storage Temperature: Store desiccated at −20°C long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.

    Light Sensitivity: Protect from light

    Reconstitution: Dissolve in sterile water or PBS (pH 7.4); avoid repeated freeze-thaw cycles

    Available Strengths: 5 mg · 10 mg · 15 mg · 20 mg · 30 mg · 40 mg

    SKU (5 mg): VE-S3M4-005

    SKU (10 mg): VE-S3M4-010

    SKU (15 mg): VE-S3M4-015

    SKU (20 mg): VE-S3M4-020

    SKU (30 mg): VE-S3M4-030

    SKU (40 mg): VE-S3M4-040

    • What is this product?
      Semaglutide (VE-S3M4) is supplied as a lyophilized GLP-1 receptor agonist peptide (CAS 910463-68-2, MW 4113.58 g/mol) intended for laboratory research use only. It is the active peptide in Ozempic® and Rybelsus®.
    • What purity and testing methods are used?
      Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity. A lot-specific COA is included with every order. Scan the QR code on the label to access your lot documentation.
    • What are the key chemical identifiers?
      CAS 910463-68-2 · Molecular formula C₁₈₇H₂₉₁N₄₅O₅₉ · MW 4113.58 g/mol · Synonyms: NNC0113-0217, semaglutide GLP-1 analog, Ozempic active ingredient.
    • How is semaglutide reconstituted for research use?
      Dissolve in sterile water or PBS (pH 7.4) at ~1 mg/mL. DMSO (~5 mg/mL) may be used for organic solvent applications. Store desiccated at −20°C long-term. Avoid repeated freeze-thaw cycles. Protect from light.
    • Where can I find research literature on semaglutide?
      PubMed indexes 3,500+ studies on semaglutide. See the Research References section for direct PubMed and PubChem links. Key journals: Diabetes, Cell Metabolism, NEJM, JCEM.
    • What is the recommended storage upon receipt?
      Upon receipt, store immediately at −20°C in a desiccated environment. Short-term storage at 2–8°C is acceptable. Do not leave at room temperature for extended periods. Inspect the vial for integrity and contact support if damaged.
    • What is a COA and why does it matter?
      A Certificate of Analysis (COA) documents lot-specific analytical results including purity (HPLC), identity (MS), and appearance. Each VE-S3M4 lot ships with a COA accessible via QR code on the label. Review the COA before use to confirm identity and purity meet your research requirements.

  • PubMed Literature Search — Semaglutide
    Primary literature · 3,500+ indexed studies
    Open PubMed

    PubChem Compound Record
    CAS 910463-68-2 · Full chemical data, bioassays, patents
    View Record

    Novo Nordisk / Supplier Product Insert
    Solubility data, storage protocol, receptor binding summary
    Download PDF

Additional information

Dosage

10mg, 15mg, 20mg, 30mg, 40mg, 50mg, 5mg

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