T1R2
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T1R2

Price range: $30.00 through $40.00

T1R2 | Dual Agonist Research Peptide

Metabolic & Multi-Pathway Signaling Research

T1R2 is a synthetic dual agonist peptide commonly referenced in metabolic
signaling studies, glucoregulatory pathway analysis, endocrine communication
research, and cellular energy regulation models.

In plain terms: T1R2 is used in lab studies to investigate how dual-action cell receptors coordinate energy use and metabolic signaling.

  • Lyophilized research peptide
  • ≥98% purity by HPLC analysis
  • Lot-specific COA and laboratory documentation available

Research Use Only — Not for Human Consumption.

SKU: VE-T1R2 Category:

Description

  • About Tirzepatide (Mounjaro® active ingredient)

    Tirzepatide — the active peptide in Mounjaro® (CAS 2023788-19-2) — is a first-in-class dual GIP/GLP-1 receptor agonist (the "twincretin") with a C20 fatty diacid chain enabling albumin binding and once-weekly dosing pharmacokinetics (~5-day half-life). It co-activates both the glucose-dependent insulinotropic polypeptide receptor (GIPR) and the glucagon-like peptide-1 receptor (GLP-1R), producing additive or synergistic effects on insulin secretion and energy homeostasis compared to selective GLP-1R agonists. Used in research to dissect the relative contributions of GIP and GLP-1 signaling in metabolic regulation, β-cell function, and CNS appetite pathways. Supplied as lyophilized peptide for non-clinical research use only. Internal catalog code: VE-TIRZ.

    COMMON RESEARCH APPLICATIONS

    Dual GIP/GLP-1 Receptor Pharmacology
    Tirzepatide activates both GIPR and GLP-1R with balanced potency. Used to compare dual vs. selective agonism in cAMP signaling, β-arrestin recruitment, and receptor internalization in HEK293 cell models co-expressing GIPR and GLP-1R.

    β-Cell Function Research
    Tool compound for studying augmented insulin secretion through dual incretin receptor activation in INS-1 and MIN6 pancreatic β-cell models; distinguishing GIP vs. GLP-1 contribution at different glucose concentrations.

    Metabolic & Adipose Tissue Studies
    GIPR activation in adipose tissue drives lipolysis modulation; used to study fat depot dynamics, FFA flux, and lipid metabolism in adipocyte cell models alongside GLP-1R-driven CNS effects.

    Comparative GLP-1R Agonist Benchmarking
    Reference standard for comparing dual GIPR/GLP-1R agonism vs. selective GLP-1R agonists (semaglutide) and triple agonists (retatrutide) in the same experimental system.

  • Chemical Identity

    Compound Name: Tirzepatide

    Synonyms: Mounjaro active ingredient · LY3298176 · GIP/GLP-1 dual agonist · twincretin

    CAS Number: 2023788-19-2

    EC Number: N/A (synthetic peptide)

    Molecular Formula: C₂₂₅H₃₄₈N₄₈O₆₈S

    Molecular Weight: 4813.50 g/mol

    Internal Catalog Code: VE-TIRZ

    Physical Properties

    Appearance: White to off-white lyophilized powder

    Solubility (water): ~1 mg/mL in sterile water or PBS (pH 7.4)

    Solubility (organic): Soluble in DMSO (~5 mg/mL)

    Hygroscopic: Yes — store desiccated

    Quality & Testing

    Purity: ≥98% (HPLC)

    Testing Method : Reverse-phase HPLC · MS confirmation · sequence verification

    Verification

    COA: Lot-specific, included with order (QR on label)

    SDS Supplier : See SDS/MSDS · OSHA HCS / GHS compliant

    Handling & Storage

    Storage Temperature: Store desiccated at −20°C long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.

    Light Sensitivity: Protect from light

    Reconstitution: Dissolve in sterile water or PBS (pH 7.4); avoid repeated freeze-thaw cycles

    Available Strengths: 5 mg · 10 mg · 15 mg · 20 mg · 30 mg · 40 mg · 50 mg · 60 mg · 120 mg

    SKU (5 mg): VE-TIRZ-005

    SKU (10 mg): VE-TIRZ-010

    SKU (15 mg): VE-TIRZ-015

    SKU (20 mg): VE-TIRZ-020

    SKU (30 mg): VE-TIRZ-030

    SKU (40 mg): VE-TIRZ-040

    SKU (50 mg): VE-TIRZ-050

    SKU (60 mg): VE-TIRZ-060

    SKU (120 mg): VE-TIRZ-120

    • What is this product?
      Tirzepatide (VE-TIRZ) is supplied as a lyophilized dual GIP/GLP-1 receptor agonist peptide (CAS 2023788-19-2, MW 4813.50 g/mol) intended for laboratory research use only. It is the active peptide in Mounjaro® and Zepbound®.
    • What purity and testing methods are used?
      Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity. A lot-specific COA is included with every order. Scan the QR code on the label to access your lot documentation.
    • What are the key chemical identifiers?
      CAS 2023788-19-2 · Molecular formula C₂₂₅H₃₄₈N₄₈O₆₈S · MW 4813.50 g/mol · Synonyms: LY3298176, Mounjaro active ingredient, GIP/GLP-1 dual agonist, twincretin.
    • How is tirzepatide reconstituted for research use?
      Dissolve in sterile water or PBS (pH 7.4) at ~1 mg/mL. DMSO (~5 mg/mL) is suitable for organic applications. Store desiccated at −20°C long-term. Avoid repeated freeze-thaw cycles. Protect from light.
    • How does tirzepatide differ from semaglutide in research applications?
      Semaglutide selectively activates GLP-1R; tirzepatide co-activates both GLP-1R and GIPR. This dual mechanism makes tirzepatide useful for studies comparing incretin receptor contributions and for benchmarking downstream signaling differences in the same cell model.
    • What is the recommended storage upon receipt?
      Store immediately at −20°C in a desiccated environment upon receipt. Short-term at 2–8°C is acceptable. Do not leave at room temperature. Inspect the vial for integrity and contact support if damaged.
    • What is a COA and why does it matter?
      A COA documents lot-specific analytical results including purity (HPLC ≥98%), identity (MS confirmation), and appearance. Each VE-TIRZ lot ships with a QR-accessible COA. Review before use to confirm identity and purity meet your experimental requirements.

  • PubMed Literature Search — Tirzepatide
    Primary literature · 1,800+ indexed studies
    Open PubMed

    PubChem Compound Record
    CAS 2023788-19-2 · Full chemical data, bioassays, patents
    View Record

    Eli Lilly / Supplier Product Insert
    Solubility data, storage protocol, dual receptor binding summary
    Download PDF

Additional information

Dosage

100mg, 10mg, 120mg, 15mg, 20mg, 30mg, 40mg, 50mg, 5mg, 60mg

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