Bronchogen

Bronchogen

$102.00

Bronchogen 20 mg

What is BRON

Bronchogen (20 mg) is supplied strictly for laboratory research and analytical applications, commonly referenced in endocrine axis, organ-signaling, and regulatory pathway studies.

Specifications:
  • Strength: 20mg per vial
  • Format: Lyophilized powder
  • Category: Cellular & Regulatory Signaling
  • Documentation: COA available

Research Use Only — Not for Human Consumption.

SKU: VE-BRON-020 Category:

Description

  • About Bronchogen

    Bronchogen — a synthetic Ala-Glu-Asp-Leu tetrapeptide (CAS 135558-11-1) from the Khavinson peptide bioregulator series — is a tissue-specific peptide studied as a model bronchial cytoprotective signal in respiratory epithelial research. It is supplied as a laboratory-grade lyophilized powder intended strictly for analytical and non-clinical research applications.

    As a member of the short peptide bioregulator family developed by the St. Petersburg Institute of Bioregulation, Bronchogen is investigated for its selectivity toward bronchial and lung tissue signaling models. Researchers use Bronchogen in bronchial epithelial cell lines (BEAS-2B, A549) and primary airway cultures to examine effects on inflammatory cytokine signaling (NF-κB, IL-6, IL-8), epithelial barrier integrity, and cellular stress response pathways under standardized in vitro conditions.

    COMMON RESEARCH APPLICATIONS

    Respiratory Epithelial Inflammation Pathway Research
    Bronchogen is examined in BEAS-2B and A549 bronchial epithelial models under LPS or TNF-α challenge to study NF-κB pathway modulation, IL-6/IL-8 cytokine expression, and anti-inflammatory signaling endpoint characterization.

    Airway Barrier Integrity Studies
    Used in air-liquid interface (ALI) bronchial epithelial models to assess tight junction protein expression (ZO-1, claudin-3), transepithelial electrical resistance (TEER), and mucin secretion pathway modulation.

    Cellular Stress & Cytoprotection Assays
    Examined in oxidative stress and hypoxia challenge models to characterize Bronchogen effects on HIF-1α expression, Nrf2 pathway activation, and cell viability endpoints in respiratory cell lines.

    Comparative Khavinson Peptide Screening
    Benchmarked alongside related tissue-specific bioregulators (Cardiogen, Testagen, Thymalin) to characterize tissue selectivity profiles and shared vs. distinct signaling features in the short peptide bioregulator class.

  • Chemical Identity

    Compound Name: Bronchogen

    Synonyms: Ala-Glu-Asp-Leu · Khavinson bronchial peptide · lung cytoprotective tetrapeptide

    CAS Number: 135558-11-1

    EC Number: N/A (synthetic tetrapeptide)

    Molecular Formula: C14H24N6O5

    Molecular Weight: 356.38 g/mol

    Physical Properties

    Appearance: White to off-white lyophilized powder

    Solubility (water): ~5 mg/mL in sterile water or PBS (pH 7.0)

    Solubility (organic): Limited solubility in organic solvents

    Hygroscopic: Yes — store desiccated

    Quality & Testing

    Purity: ≥98% (HPLC)

    Testing Method : Reverse-phase HPLC · MS confirmation · sequence verification

    Verification

    COA: Lot-specific, included with order (QR on label)

    SDS Supplier : Velox Research Chemicals

    SDS Revision: Current lot · OSHA HCS / GHS compliant

    Handling & Storage

    Storage Temperature: Store desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.

    Light Sensitivity: Protect from light

    Reconstitution: Dissolve in sterile water or PBS (pH 7.0); use immediately or aliquot and store at −80°C

    Available Strengths: 20 mg

    SKU (20 mg): VE-BRON-020

    • What is this product?
      Bronchogen (CAS 135558-11-1, MW 356.38 g/mol) is a synthetic Ala-Glu-Asp-Leu tetrapeptide from the Khavinson bioregulator peptide series, supplied as a lyophilized powder for laboratory research use only. It is studied as a model bronchial cytoprotective peptide in respiratory epithelial signaling research.
    • What purity and testing methods are used?
      Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity with sequence verification. A lot-specific COA is included with every order, accessible via QR code on the label.
    • What are the key chemical identifiers?
      CAS 135558-11-1 · Molecular formula C₁₄H₂₄N₆O₅ · MW 356.38 g/mol · Sequence: Ala-Glu-Asp-Leu · Synonyms: Khavinson bronchial peptide, lung cytoprotective tetrapeptide.
    • How is Bronchogen reconstituted for research use?
      Dissolve in sterile water or PBS (pH 7.0) at ~5 mg/mL. Use immediately or aliquot and store at −80°C. Avoid repeated freeze-thaw cycles. Protect from light.
    • What is the recommended storage upon receipt?
      Store immediately at −20°C desiccated. Short-term at 2–8°C is acceptable for up to 2 weeks. Inspect vials for integrity upon receipt.
    • What is a COA and why does it matter?
      A COA documents lot-specific purity (HPLC ≥98%), sequence verification (MS), and appearance. Each lot ships with a QR-accessible COA. Review before use to confirm identity and purity meet your experimental requirements.

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