Description
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About Thymalin
Thymalin — a synthetic octapeptide complex (CAS 62304-98-7, sequence Ala-Glu-Asp-Gly-Pro-Lys-Phe-Leu) from the Khavinson peptide bioregulator series — is a tissue-specific peptide studied as a model thymic immune modulation signal in immunogerontology and T-cell biology research. It is supplied as a laboratory-grade lyophilized powder intended strictly for analytical and non-clinical research applications
Thymalin is one of the most extensively characterized peptides in the Khavinson series, with a substantial preclinical literature spanning thymic cell signaling, T-lymphocyte differentiation, and age-associated immune dysfunction models. Unlike the shorter Khavinson tetrapeptides, Thymalin is an octapeptide that may have a more complex receptor interaction profile in thymocyte and peripheral T-cell models. Researchers use Thymalin in primary thymocyte, Jurkat T-cell, and human peripheral blood mononuclear cell (PBMC) models to examine T-cell subset differentiation markers (CD4/CD8, Th1/Th2 balance), thymic epithelial cell signaling (FOXN1, CCL25), IL-2/IL-7 T-cell survival pathway activation, and thymosin β4/α1 comparative signaling under standardized in vitro conditions.
COMMON RESEARCH APPLICATIONS
T-Lymphocyte Differentiation & Thymic Signaling
T-Thymalin is examined in primary thymocyte and Jurkat T-cell models to study CD4/CD8 lineage commitment markers, IL-2/IL-7 receptor expression, FOXP3 Treg differentiation, and thymic selection pathway gene expression under aging-model or irradiation challenge conditions.PBMC Immune Modulation Studies
Used in human PBMC proliferation (CFSE dilution) and cytokine secretion (Luminex, ELISA) assays under PHA/ConA mitogen stimulation to characterize Thymalin effects on Th1/Th2/Th17/Treg balance, IFN-γ, IL-4, IL-17, and IL-10 secretion endpoint profiles.Thymic Epithelial Cell (TEC) Signaling
Examined in human thymic epithelial cell cultures to study FOXN1, CCL25, and CXCL12 expression as markers of thymic microenvironment maintenance; used in aging and post-irradiation thymic regeneration models alongside Thymosin α1 as a comparator compound.Comparative Khavinson Immune Peptide Benchmarking
Benchmarked alongside Thymalin (8 aa), Crystagen (3 aa Glu-Asp-Pro), and Vilon (2 aa Lys-Glu) to characterize the relationship between peptide length and immune signaling breadth within the thymic short peptide bioregulator class. -
Chemical Identity
Compound Name: Thymalin
Internal Catalog Code: Thymalin
CAS Number: 62304-98-7
Molecular Formula: C32H54N10O11
Molecular Weight: 742.84 g/mol
Physical Properties
Form/Appearance: Lyophilized powder
Quality & Testing
Purity: As listed on lot-specific COA
Testing Method : HPLC (as applicable) · identity confirmation per COA
Verification
COA: Lot-specific, included with order (QR on label)
Handling & Storage
Storage Temperature: Store desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.
Light Sensitivity: Protect from light
Moisture: Store desiccated when applicable
Available Strengths: 10 mg
SKU (10 mg): VE-THYM-010
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What is this product?
Thymalin (CAS 62304-98-7, MW 742.84 g/mol, C₃₂H₅₄N₁₀O₁₁) is a synthetic octapeptide from the Khavinson bioregulator series, supplied as a lyophilized powder for laboratory research use only. It is studied as a model thymic immune modulation peptide. Available as VE-THYM-010 (10 mg).
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What purity and testing methods are used?
Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity with sequence verification. A lot-specific COA is included with every order, accessible via QR code on the label.
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What are the key chemical identifiers?
CAS 62304-98-7 · Molecular formula C₃₂H₅₄N₁₀O₁₁ · MW 742.84 g/mol · Synonyms: Khavinson thymic octapeptide, thymic bioregulator peptide, immune modulation octapeptide.
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How is Thymalin reconstituted for research use?
Dissolve in sterile water or PBS (pH 7.0) at ~5 mg/mL. Use immediately or aliquot and store at −80°C. Avoid repeated freeze-thaw cycles. Protect from light.
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What is the recommended storage upon receipt?
Store immediately at −20°C desiccated. Short-term at 2–8°C acceptable for up to 2 weeks. Inspect vials for integrity upon receipt.
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What is a COA and why does it matter?
A COA documents lot-specific purity (HPLC ≥98%), sequence verification (MS), and appearance. Each Thymalin lot ships with a QR-accessible COA. Review before use to confirm identity and purity meet your experimental requirements.
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What is this product?
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