Livagen

Livagen

$99.99

Livagen 20 mg

What is LIVA

Livagen (20 mg) is supplied strictly for laboratory research and analytical applications, commonly referenced in endocrine axis, organ-signaling, and regulatory pathway studies.

Specifications:
  • Strength: 20 mg per vial
  • Format: Lyophilized powder
  • Category: Cellular & Regulatory Signaling
  • Documentation: COA available

Research Use Only — Not for Human Consumption.

1000 in stock

SKU: VE-LIVA-020 Category:

Description

  • About Livagen

    Livagen — a synthetic Lys-Glu-Asp-Pro tetrapeptide (CAS 135537-13-2) from the Khavinson peptide bioregulator series — is a tissue-specific peptide studied as a model hepatic and immune cytoprotective signal in liver biology and chromatin remodeling research. It is supplied as a laboratory-grade lyophilized powder intended strictly for analytical and non-clinical research applications.

    As a member of the short peptide bioregulator family developed by the St. Petersburg Institute of Bioregulation, Livagen is investigated for its ability to activate heterochromatin gene expression and normalize chromatin structure in aged cell models — a mechanistically notable feature within the Khavinson series. Researchers use Livagen in HepG2, HepaRG, and primary hepatocyte models to examine effects on liver-specific gene expression, chromatin remodeling pathway markers (histone acetylation, HDAC activity), oxidative stress response (Nrf2/HO-1), and cellular aging markers under standardized in vitro conditions.

    COMMON RESEARCH APPLICATIONS

    Hepatocyte Gene Expression & Chromatin Remodeling
    Livagen is examined in HepG2 and HepaRG models under aging and oxidative stress conditions to study heterochromatin decondensation, histone acetylation changes (H3K9ac, H3K14ac), HDAC pathway modulation, and age-associated gene reactivation endpoint markers.

    Hepatic Oxidative Stress & Nrf2 Pathway Research
    Used in primary hepatocyte and HepG2 models under H₂O₂ and tBHP challenge to characterize Nrf2/HO-1/NQO1 pathway activation, cytochrome P450 enzyme expression (CYP3A4, CYP2D6), and hepatocellular viability endpoint changes.

    Hepatic Aging Biomarker Studies
    Studied alongside other short peptide bioregulators in aging hepatocyte models to characterize effects on p21/p53/SA-β-gal senescence markers, mitochondrial membrane potential, and cellular lifespan-associated gene expression patterns.

    Comparative Khavinson Hepatic Peptide Screening
    Benchmarked alongside related hepatic bioregulators (Ovagen) and other Khavinson tetrapeptides to characterize tissue-selective hepatocyte signaling profiles and shared vs. distinct chromatin remodeling features within the short peptide bioregulator class.

  • Chemical Identity

    Compound Name: Livagen

    Internal Catalog Code: Livagen

    CAS Number: 135537-13-2

    Molecular Formula: C22H38N6O7

    Molecular Weight: 498.57 g/mol

    Physical Properties

    Form/Appearance: Lyophilized powder

    Quality & Testing

    Purity: As listed on lot-specific COA

    Testing Method : HPLC (as applicable) · identity confirmation per COA

    Verification

    COA: Lot-specific, included with order (QR on label)

    Handling & Storage

    Storage Temperature: Store desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.

    Light Sensitivity: Protect from light

    Moisture: Store desiccated when applicable

    Available Strengths: 20 mg

    SKU (20 mg): VE-LIVA-020

    • What is this product?
      Livagen (CAS 135537-13-2, MW 498.57 g/mol, C₂₂H₃₈N₆O₇) is a synthetic Lys-Glu-Asp-Pro tetrapeptide from the Khavinson bioregulator series, supplied as a lyophilized powder for laboratory research use only. It is studied as a model hepatic cytoprotective and chromatin remodeling peptide. Available as VE-LIVA-020 (20 mg).
    • What purity and testing methods are used?
      Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity with sequence verification (Lys-Glu-Asp-Pro confirmed). A lot-specific COA is included with every order, accessible via QR code on the label.
    • What are the key chemical identifiers?
      CAS 135537-13-2 · Molecular formula C₂₂H₃₈N₆O₇ · MW 498.57 g/mol · Sequence: Lys-Glu-Asp-Pro · Synonyms: KEDP, Khavinson liver peptide, hepatic cytoprotective tetrapeptide.
    • How is Livagen reconstituted for research use?
      Dissolve in sterile water or PBS (pH 7.0) at ~5 mg/mL. Use immediately or aliquot and store at −80°C. Avoid repeated freeze-thaw cycles. Protect from light.
    • What is the recommended storage upon receipt?
      Store immediately at −20°C desiccated. Short-term at 2–8°C acceptable for up to 2 weeks. Inspect vials for integrity upon receipt.
    • What is a COA and why does it matter?
      A COA documents lot-specific purity (HPLC ≥98%), sequence verification (MS), and appearance. Each Livagen lot ships with a QR-accessible COA. Review before use to confirm identity and purity meet your experimental requirements.

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