VIP

VIP

$89.99

VIP 5 mg

What is VIPX

VIP (5 mg) is supplied strictly for laboratory research and analytical applications, commonly referenced in endocrine axis, organ-signaling, and regulatory pathway studies.

Specifications:
  • Strength: 5 mg per vial
  • Format: Lyophilized powder
  • Category: Cellular & Regulatory Signaling
  • Documentation: COA available

Research Use Only — Not for Human Consumption.

1000 in stock

SKU: VE-VIPX-005-1 Category:

Description

  • About VIP

    VIP (Vasoactive Intestinal Peptide, CAS 37221-79-7) is a 28-amino acid neuropeptide and immunomodulatory hormone originally isolated from porcine duodenum. It is among the most pleiotropic neuropeptides in the mammalian autonomic nervous system, acting on two GPCR receptor subtypes — VPAC1 (VIPR1) and VPAC2 (VIPR2) — both of which signal via Gs/cAMP/PKA pathways. It is supplied as a laboratory-grade lyophilized powder intended strictly for analytical and non-clinical research applications.

    VIP is expressed throughout the enteric nervous system (ENS), central and peripheral autonomic neurons, and immune cells (T cells, mast cells, dendritic cells). Its diverse research applications span smooth muscle relaxation, neuroimmune communication, circadian pacemaker regulation (SCN), and anti-inflammatory cytokine modulation. Researchers use VIP in intestinal smooth muscle (ICC, SMC), T-cell, dendritic cell, SCN organotypic slice, and pulmonary smooth muscle models to study VPAC1/VPAC2 receptor pharmacology, cAMP/PKA/CREB signaling kinetics, VIP-mediated Th2/Treg immune polarization, and enteric neurotransmission under standardized in vitro conditions.

    COMMON RESEARCH APPLICATIONS

    VPAC1/VPAC2 Receptor Pharmacology
    VIP is the reference VPAC1/VPAC2 agonist used in CHO-VPAC1, CHO-VPAC2, and HEK293 models for cAMP accumulation, Gs/adenylate cyclase kinetics, β-arrestin recruitment, and receptor internalization assays; used to benchmark receptor subtype selectivity for novel VPAC ligands.

    Enteric Nervous System (ENS) & Smooth Muscle Signaling
    Used in intestinal smooth muscle cell and ICC (interstitial cell of Cajal) models to study VIP-mediated cAMP/PKA → MLC phosphatase activation, smooth muscle relaxation, and neurotransmission in co-culture ENS-SMC models.

    Neuroimmune & T-Cell Polarization Research
    Used in dendritic cell and T-cell models to characterize VIP-driven Th2 polarization (IL-4/IL-13 upregulation), Treg induction (FOXP3/IL-10), and innate immune suppression (TNF-α, IL-12 downregulation) via VPAC1/VPAC2 on immune cells.

    Circadian Pacemaker & SCN Signaling
    Tool compound for studying VPAC2-mediated synchronization of the suprachiasmatic nucleus (SCN) molecular clock. Used in SCN organotypic slice models to characterize VIP-driven Per1/Per2 gene induction, CREB phosphorylation, and circadian phase-resetting endpoint markers.

  • Chemical Identity

    Compound Name: VIP

    Internal Catalog Code: VIP

    CAS Number: 37221-79-7

    Molecular Formula: C147H237N43O43S

    Molecular Weight: 3325.80 g/mol

    Physical Properties

    Form/Appearance: Lyophilized powder

    Quality & Testing

    Purity: As listed on lot-specific COA

    Testing Method : HPLC (as applicable) · identity confirmation per COA

    Verification

    COA: Lot-specific, included with order (QR on label)

    Handling & Storage

    Storage Temperature: Store desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.

    Light Sensitivity: Protect from light

    Moisture: Store desiccated when applicable

    Available Strengths: 5 mg

    SKU (5 mg): VE-VIPX-005

    • What is this product?
      VIP (Vasoactive Intestinal Peptide, CAS 37221-79-7, MW 3325.80 g/mol, C₁₄₇H₂₃₇N₄₃O₄₃S) is supplied as a lyophilized 28-amino acid neuropeptide for laboratory research use only. It is the standard VPAC1/VPAC2 agonist tool compound in neuroimmunology and ENS research. Available as VE-VIPX-005 (5 mg) and VE-VIPX-010 (10 mg).
    • What purity and testing methods are used?
      Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity with sequence verification. A lot-specific COA is included with every order, accessible via QR code on the label.
    • What are the key chemical identifiers?
      CAS 37221-79-7 · Molecular formula C₁₄₇H₂₃₇N₄₃O₄₃S · MW 3325.80 g/mol · Synonyms: Vasoactive Intestinal Peptide, VIP-1, VPAC receptor ligand, enteric neuropeptide VIP.
    • What signaling pathways does VIP engage in research models?
      VIP signals through VPAC1 (constitutively expressed in T cells, liver, lung) and VPAC2 (predominantly expressed in smooth muscle, SCN, pancreas): Gs/Adenylate cyclase/cAMP/PKA → CREB phosphorylation; PKA-dependent phosphodiesterase modulation; Gs/cAMP-mediated smooth muscle relaxation (MLC dephosphorylation); VIP-mediated IL-10/IL-4 Th2 polarization and Treg induction in immune models.
    • How is VIP reconstituted for research use?
      Dissolve in sterile water or PBS (pH 7.4) at ~1 mg/mL. VIP is susceptible to aggregation at high concentrations — add 0.1% BSA or 1% acetic acid to improve stability if aggregation occurs. Aliquot and store at −80°C. Avoid repeated freeze-thaw. Protect from light.
    • What is the recommended storage upon receipt?
      Store immediately at −20°C desiccated. For maximum stability, −80°C is preferred. Short-term 2–8°C acceptable for active use periods. Inspect vials for integrity upon receipt.
    • What is a COA and why does it matter?
      A COA documents lot-specific purity (HPLC ≥98%), MS identity confirmation, and sequence verification. Each VIP lot ships with a QR-accessible COA. Review before use — VIP receptor pharmacology studies require verified sequence identity to distinguish VPAC1 versus VPAC2 selectivity effects correctly.

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