KPV
KPV - Image 2

KPV

$53.00

KPV | Tripeptide Tri-Amino Acid Fragment

Cellular Inflammation & Melanocortin Research

KPV (Lysine-Proline-Valine) is a synthetic tripeptide fragment corresponding to the C-terminus of alpha-MSH, commonly referenced in inflammatory signaling models, melanocortin receptor pathway analysis, and intestinal epithelial barrier stability research.

In plain terms: KPV is used in lab research to observe how short-chain amino acids signal cells to turn down inflammatory responses and reinforce epithelial barrier walls.

  • 10 mg lyophilized research peptide
  • ≥98% purity by HPLC analysis
  • Lot-specific COA and laboratory documentation available

Research Use Only — Not for Human Consumption.

SKU: VE-KPVX Category:

Description

  • About KPV

    KPV — Lys-Pro-Val (CAS 65982-89-0) — is a C-terminal tripeptide fragment of α-MSH (α-melanocyte-stimulating hormone) that retains the core anti-inflammatory signaling properties of the full 13-amino acid peptide. It is supplied as a laboratory-grade lyophilized powder intended strictly for analytical and non-clinical research applications.

    α-MSH exerts its anti-inflammatory effects through melanocortin receptors (MC1R, MC3R) and by directly modulating NF-κB signaling in immune and epithelial cells. KPV, as the minimal bioactive fragment, has been shown to penetrate intestinal epithelial cells and access intracellular targets independent of surface receptor binding — a mechanistically distinct feature that makes it valuable for studying non-receptor-mediated melanocortin anti-inflammatory pathways. Researchers use KPV in HT-29, Caco-2 intestinal epithelial, and RAW 264.7 macrophage models to study NF-κB pathway suppression, IL-8/TNF-α cytokine modulation, skin barrier integrity, and mucosal immune signaling under inflammatory challenge conditions.

    COMMON RESEARCH APPLICATIONS

    Intestinal Epithelial Inflammation & Barrier Research
    KPV is examined in Caco-2 and HT-29 intestinal epithelial models under LPS or IL-1β challenge to study NF-κB p65 pathway suppression, IL-8/TNF-α cytokine attenuation, tight junction protein expression (ZO-1, occludin), and TEER restoration as barrier integrity endpoints.

    Skin Inflammation & Melanocortin Signaling
    Used in HaCaT keratinocyte and HDFa fibroblast models to examine α-MSH C-terminal fragment activity on MC1R-independent NF-κB suppression, IL-6/IL-8 secretion, and Nrf2-mediated antioxidant pathway activation under inflammatory challenge.

    Intracellular Peptide Penetration Studies
    KPV s small size enables cellular uptake independent of surface receptor engagement. Used in confocal microscopy and cell fractionation assays to study intracellular distribution, NF-κB nuclear translocation inhibition, and receptor-independent vs. receptor-dependent anti-inflammatory mechanisms.

    Comparative α-MSH Fragment Benchmarking
    Benchmarked against full-length α-MSH (13 aa), Ac-α-MSH, and tripeptide analogs in MC1R/MC3R pharmacology assays to characterize the minimal active pharmacophore for anti-inflammatory activity and receptor-binding vs. receptor-independent potency ratios.

  • Chemical Identity

    Compound Name: KPV

    Internal Catalog Code: KPV

    CAS Number: 65982-89-0

    Molecular Formula: C16H29N5O4

    Molecular Weight: 355.44 g/mol

    Physical Properties

    Form/Appearance: Lyophilized powder

    Quality & Testing

    Purity:

    Testing Method : HPLC (as applicable) · identity confirmation per COA

    Verification

    COA: Lot-specific, included with order (QR on label)

    Handling & Storage

    Storage Temperature: Store desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.

    Light Sensitivity: Protect from light

    Moisture: Store desiccated when applicable

    Available Strengths: 10 mg

    SKU (10 mg): VE-KPVX-010

    • What is this product?
      KPV (Lys-Pro-Val, CAS 65982-89-0, MW 355.44 g/mol, C₁₆H₂₉N₅O₄) is supplied as a lyophilized synthetic tripeptide — the C-terminal anti-inflammatory fragment of α-MSH — for laboratory research use only. Available as VE-KPVX-010 (10 mg).
    • What purity and testing methods are used?
      Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity with sequence verification. A lot-specific COA is included with every order, accessible via QR code on the label.
    • What are the key chemical identifiers?
      CAS 65982-89-0 · Molecular formula C₁₆H₂₉N₅O₄ · MW 355.44 g/mol · Sequence: Lys-Pro-Val · Synonyms: α-MSH(11-13), melanocortin C-terminal tripeptide, KPV tripeptide.
    • How is KPV reconstituted for research use?
      Dissolve in sterile water or PBS (pH 7.0) at ~5 mg/mL. Use immediately or aliquot and store at −80°C. Avoid repeated freeze-thaw cycles. Protect from light.
    • What is the recommended storage upon receipt?
      Store immediately at −20°C desiccated. Short-term at 2–8°C acceptable for up to 2 weeks. Inspect vials for integrity upon receipt.
    • What is a COA and why does it matter?
      A COA documents lot-specific purity (HPLC ≥98%), sequence verification (MS: Lys-Pro-Val confirmed), and appearance. Each KPV lot ships with a QR-accessible COA. Review before use to confirm identity and purity meet your experimental requirements.

  • PubMed Literature Search — KPV
    Primary literature · curated search
    Open PubMed

    PubChem Compound Record
    Full chemical data, bioassays, patents
    View Record

    Source Document / Insert
    Supplier insert or supporting SDS source
    Download PDF

Additional information

Dosage

10mg

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