Description
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About Ipamorelin (selective GHRP / growth hormone secretagogue)
Ipamorelin — NNC 26-0161 (CAS 170851-70-4) — is a synthetic pentapeptide growth hormone secretagogue (GHS) and selective ghrelin receptor (GHSR-1a) agonist. It is among the most selective GHRPs studied, notable for stimulating GH release without significantly affecting cortisol, prolactin, or ACTH at pharmacologically relevant concentrations — a selectivity profile that distinguishes it from earlier-generation GHRPs such as GHRP-2 and GHRP-6.
Ipamorelin acts synergistically with GHRH analogs (e.g., CJC-1295, sermorelin) on pituitary somatotroph cells, making the ipamorelin + CJC-1295 combination a frequently used research model for studying pulsatile GH secretion and GHSR-1a pharmacology. Supplied as lyophilized pentapeptide for non-clinical research use only.
COMMON RESEARCH APPLICATIONS
GHSR-1a Receptor Pharmacology
Selective ghrelin receptor agonist; used to study GHSR-1a activation, β-arrestin recruitment, and receptor desensitization in pituitary somatotroph cell lines (GH3, MtT/S) and HEK293-GHSR models.GH Pulse & Somatotroph Signaling
Ipamorelin stimulates GH release via GHSR-1a without cortisol/ACTH co-stimulation. Used in pituitary cell models to characterize selective somatotroph signaling and compare GH pulse amplitude/frequency against GHRP-2 and GHRP-6.Synergistic GHRH/GHRP Combination Studies
Combines synergistically with CJC-1295 and sermorelin to amplify GH release in vitro. Used in pituitary explant and primary somatotroph models to study GHRH receptor + GHSR-1a co-activation kinetics.IGF-1 Pathway Research
Downstream of GH release, used in hepatocyte models to study GH-stimulated IGF-1 synthesis and JAK2/STAT5 pathway activation as a tool for probing the GH/IGF-1 axis in preclinical systems. -
Chemical Identity
Compound Name: Ipamorelin
Synonyms: NNC 26-0161 · GHRP Ipamorelin · Ipam · growth hormone releasing peptide Ipamorelin
CAS Number: 170851-70-4
EC Number: N/A (synthetic pentapeptide)
Molecular Formula: C₃₈H₄₉N₉O₅
Molecular Weight: 711.90 g/mol
Physical Properties
Appearance: White to off-white lyophilized powder
Solubility (water): ~5 mg/mL in sterile water or PBS (pH 7.0)
Solubility (organic): Soluble in DMSO (~10 mg/mL); limited in ethano
Hygroscopic: Yes — store desiccated
Quality & Testing
Purity: ≥98% (HPLC)
Testing Method : Reverse-phase HPLC · MS confirmation
Verification
COA: Lot-specific, included with order (QR on label)
SDS Supplier : See SDS/MSDS · OSHA HCS / GHS compliant
Handling & Storage
Storage Temperature: Store desiccated at −20°C long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.
Light Sensitivity: Protect from light
Reconstitution: Dissolve in sterile water or PBS (pH 7.0) at ~5 mg/mL; stable at room temperature for up to 4 hours post-reconstitution
Available Strengths: 2 mg · 5 mg
SKU (5 mg): VE-IPAM-005
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What is this product?
Ipamorelin (NNC 26-0161) is supplied as a lyophilized selective GHSR-1a agonist pentapeptide (CAS 170851-70-4, MW 711.90 g/mol) for laboratory research use only. It is the most selective GHRP analog studied, with minimal cortisol/ACTH co-stimulation.
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What purity and testing methods are used?
Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity. A lot-specific COA is included with every order, accessible via QR code on the label.
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What are the key chemical identifiers?
CAS 170851-70-4 · Molecular formula C₃₈H₄₉N₉O₅ · MW 711.90 g/mol · Synonyms: NNC 26-0161, GHRP Ipamorelin, selective growth hormone secretagogue.
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How is ipamorelin reconstituted for research use?
Dissolve in sterile water or PBS (pH 7.0) at ~5 mg/mL. Stable at room temperature for up to 4 hours post-reconstitution. Store desiccated at −20°C long-term. Protect from light. Avoid repeated freeze-thaw cycles.
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What is the recommended storage upon receipt?
Store immediately at −20°C desiccated. Short-term at 2–8°C acceptable for up to 2 weeks. Inspect vials for integrity upon receipt.
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What is a COA and why does it matter?
A COA documents lot-specific purity (HPLC ≥98%), identity (MS), and appearance. Each ipamorelin lot ships with a QR-accessible COA. Review before use to confirm identity and purity.
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What is this product?
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