Thymalin

Thymalin

$64.00

Thymalin | Thymic Peptide Complex

Immune Signaling & Cellular Regulation Research

Thymalin is a synthetic thymic peptide complex commonly referenced in immune
signaling studies, peptide regulation research, cellular communication pathway
analysis, and immune-associated laboratory models.

In plain terms: Thymalin is studied in laboratory environments examining how
thymic peptide signaling interacts with immune-related cellular mechanisms and
regulatory communication pathways.

  • Lyophilized peptide complex
  • ≥98% purity by HPLC analysis where applicable
  • Lot-specific COA and laboratory documentation available

Research Use Only — Not for Human Consumption.

Available on backorder

SKU: VE-THYM-010 Category:

Description

  • About Thymalin

    Thymalin — a synthetic octapeptide complex (CAS 62304-98-7, sequence Ala-Glu-Asp-Gly-Pro-Lys-Phe-Leu) from the Khavinson peptide bioregulator series — is a tissue-specific peptide studied as a model thymic immune modulation signal in immunogerontology and T-cell biology research. It is supplied as a laboratory-grade lyophilized powder intended strictly for analytical and non-clinical research applications

    Thymalin is one of the most extensively characterized peptides in the Khavinson series, with a substantial preclinical literature spanning thymic cell signaling, T-lymphocyte differentiation, and age-associated immune dysfunction models. Unlike the shorter Khavinson tetrapeptides, Thymalin is an octapeptide that may have a more complex receptor interaction profile in thymocyte and peripheral T-cell models. Researchers use Thymalin in primary thymocyte, Jurkat T-cell, and human peripheral blood mononuclear cell (PBMC) models to examine T-cell subset differentiation markers (CD4/CD8, Th1/Th2 balance), thymic epithelial cell signaling (FOXN1, CCL25), IL-2/IL-7 T-cell survival pathway activation, and thymosin β4/α1 comparative signaling under standardized in vitro conditions.

    COMMON RESEARCH APPLICATIONS

    T-Lymphocyte Differentiation & Thymic Signaling
    T-Thymalin is examined in primary thymocyte and Jurkat T-cell models to study CD4/CD8 lineage commitment markers, IL-2/IL-7 receptor expression, FOXP3 Treg differentiation, and thymic selection pathway gene expression under aging-model or irradiation challenge conditions.

    PBMC Immune Modulation Studies
    Used in human PBMC proliferation (CFSE dilution) and cytokine secretion (Luminex, ELISA) assays under PHA/ConA mitogen stimulation to characterize Thymalin effects on Th1/Th2/Th17/Treg balance, IFN-γ, IL-4, IL-17, and IL-10 secretion endpoint profiles.

    Thymic Epithelial Cell (TEC) Signaling
    Examined in human thymic epithelial cell cultures to study FOXN1, CCL25, and CXCL12 expression as markers of thymic microenvironment maintenance; used in aging and post-irradiation thymic regeneration models alongside Thymosin α1 as a comparator compound.

    Comparative Khavinson Immune Peptide Benchmarking
    Benchmarked alongside Thymalin (8 aa), Crystagen (3 aa Glu-Asp-Pro), and Vilon (2 aa Lys-Glu) to characterize the relationship between peptide length and immune signaling breadth within the thymic short peptide bioregulator class.

  • Chemical Identity

    Compound Name: Thymalin

    Internal Catalog Code: Thymalin

    CAS Number: 62304-98-7

    Molecular Formula: C32H54N10O11

    Molecular Weight: 742.84 g/mol

    Physical Properties

    Form/Appearance: Lyophilized powder

    Quality & Testing

    Purity: As listed on lot-specific COA

    Testing Method : HPLC (as applicable) · identity confirmation per COA

    Verification

    COA: Lot-specific, included with order (QR on label)

    Handling & Storage

    Storage Temperature: Store desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.

    Light Sensitivity: Protect from light

    Moisture: Store desiccated when applicable

    Available Strengths: 10 mg

    SKU (10 mg): VE-THYM-010

    • What is this product?
      Thymalin (CAS 62304-98-7, MW 742.84 g/mol, C₃₂H₅₄N₁₀O₁₁) is a synthetic octapeptide from the Khavinson bioregulator series, supplied as a lyophilized powder for laboratory research use only. It is studied as a model thymic immune modulation peptide. Available as VE-THYM-010 (10 mg).
    • What purity and testing methods are used?
      Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity with sequence verification. A lot-specific COA is included with every order, accessible via QR code on the label.
    • What are the key chemical identifiers?
      CAS 62304-98-7 · Molecular formula C₃₂H₅₄N₁₀O₁₁ · MW 742.84 g/mol · Synonyms: Khavinson thymic octapeptide, thymic bioregulator peptide, immune modulation octapeptide.
    • How is Thymalin reconstituted for research use?
      Dissolve in sterile water or PBS (pH 7.0) at ~5 mg/mL. Use immediately or aliquot and store at −80°C. Avoid repeated freeze-thaw cycles. Protect from light.
    • What is the recommended storage upon receipt?
      Store immediately at −20°C desiccated. Short-term at 2–8°C acceptable for up to 2 weeks. Inspect vials for integrity upon receipt.
    • What is a COA and why does it matter?
      A COA documents lot-specific purity (HPLC ≥98%), sequence verification (MS), and appearance. Each Thymalin lot ships with a QR-accessible COA. Review before use to confirm identity and purity meet your experimental requirements.

  • PubMed Literature Search — Thymalin
    Primary literature · curated search
    Open PubMed

    PubMed Literature Search — Thymalin (Русский)
    Includes Cyrillic term: Тималин
    Open PubMed

    PubChem Compound Record
    Full chemical data, bioassays, patents
    View Record

    Source Document / Insert
    Supplier insert or supporting SDS source
    Download PDF

Related products