5-Amino-1MQ
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5-Amino-1MQ

$40.00

5-Amino-1MQ | NNMT Enzyme Inhibitor Compound | CAS 42464-96-0

Metabolic Optimization & Cellular Energy Research

5-Amino-1MQ (5-Amino-1-methylquinolinium) is a low-molecular-weight synthetic compound commonly referenced in nicotinamide N-methyltransferase (NNMT) enzyme inhibition, adipocyte metabolic scaling, cell senescence paths, and intracellular NAD+ optimization models.

In plain terms: 5-Amino-1MQ is used in research to see how blocking a specific metabolic enzyme (NNMT) forces cells to increase energy output and optimize fuel usage.

  • Lyophilized research compound
  • ≥98% purity by analytical analysis
  • Lot-specific COA and laboratory documentation available

Research Use Only — Not for Human Consumption.

SKU: VE-5AMQ-010 Category:

Description

  • 5-Amino-1MQ

    5-Amino-1MQ — 5-amino-1-methylquinolinium (CAS 5765-44-6) — is a cell-permeable small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that catalyzes the N-methylation of nicotinamide using S-adenosylmethionine (SAM) as the methyl donor. It is supplied as a laboratory-grade crystalline solid intended strictly for analytical and non-clinical research applications.

    NNMT sits at the intersection of NAD⁺ precursor metabolism and one-carbon/methyl-donor flux. By inhibiting NNMT, 5-Amino-1MQ increases cellular nicotinamide availability for NAD⁺ biosynthesis while reducing SAM consumption, shifting the methylation and bioenergetics balance in metabolically active cells. Researchers use 5-Amino-1MQ in adipocyte, hepatocyte, and skeletal muscle cell models to examine NNMT-dependent regulation of lipid storage, adipogenesis transcription programs, and mitochondrial bioenergetic capacity.

    COMMON RESEARCH APPLICATIONS

    NNMT Inhibition & NAD⁺ Precursor Flux Studies
    5-Amino-1MQ is used in cell-based assays to quantify NNMT enzymatic inhibition, changes in intracellular nicotinamide and NAD⁺ levels, and downstream shifts in NAD⁺-dependent enzyme activity (sirtuins, PARP) in metabolically active cell lines.

    Adipogenesis & Lipid Metabolism Models
    Applied in 3T3-L1 and primary preadipocyte differentiation models to examine NNMT's role in adipogenic transcription factor regulation (PPARγ, C/EBPα), lipid droplet accumulation, and lipolytic enzyme activity under NNMT-inhibited conditions.

    One-Carbon Metabolism & SAM Axis Research
    Used in hepatocyte and metabolic cell models to study NNMT-dependent SAM consumption, methyl-donor pool availability, and downstream effects on methylation-sensitive gene expression and epigenetic regulation.

    Metabolic Energy Expenditure Assays
    Examined in skeletal muscle and brown adipocyte models to assess NNMT inhibition effects on mitochondrial oxygen consumption rate (OCR), uncoupling protein expression, and cellular ATP turnover as markers of metabolic rate modulation.

  • Chemical Identity

    Compound Name: 5-Amino-1MQ

    Synonyms: 5-Amino-1-methylquinolinium iodide · 5-Amino-1-methylquinolinium · NNMT inhibitor 5-Amino-1MQ

    CAS Number: 5765-44-6

    EC Number: N/A (synthetic small molecule)

    Molecular Formula: C₁₀H₁₁IN₂

    Molecular Weight: 286.11 g/mol

    Physical Properties

    Appearance: Yellow to amber crystalline powder

    Solubility (water): Soluble in water; ~10 mg/mL

    Solubility (organic): Soluble in DMSO

    Hygroscopic: Yes — store desiccated

    Quality & Testing

    Purity: ≥98% (HPLC)

    Testing Method: Reverse-phase HPLC · MS confirmation of molecular identity

    Verification

    COA: Lot-specific, included with order (QR on label)

    SDS Revision: Current lot · OSHA HCS / GHS compliant

    Handling & Storage

    Storage Temperature: Store desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling

    Light Sensitivity: Protect from light — photosensitive quinolinium compound

    Reconstitution: Dissolve in sterile water or DMSO per assay requirements; prepare fresh working solutions where possible

    Available Strengths: 50 mg · 100 mg

    • What is this product?
      BPC-157 is supplied as a lyophilized 15-amino acid pentadecapeptide (CAS 1628202-19-6, MW 1419.50 g/mol) intended for laboratory research use only. Also known as Body Protection Compound-157 (Bepecin).
    • What purity and testing methods are used?
      Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity with sequence verification. A lot-specific COA is included with every order, accessible via QR code on the label.
    • What are the key chemical identifiers?
      CAS 1628202-19-6 · Molecular formula C₆₂H₉₈N₁₆O₂₂ · MW 1419.50 g/mol · Synonyms: Body Protection Compound-157, Bepecin, PL 14736, pentadecapeptide BPC.
    • How is BPC-157 reconstituted for research use?
      Dissolve in sterile water or PBS (pH 7.4) at ~1 mg/mL. Use immediately after reconstitution or aliquot and store at −80°C to prevent degradation. Avoid repeated freeze-thaw cycles. Protect from light.
    • What signaling pathways does BPC-157 affect in research models?
      BPC-157 has been studied for effects on FAK/paxillin signaling in fibroblasts, VEGFR2-mediated angiogenesis in endothelial cells, and nitric oxide (NO) synthase modulation. It is also studied for growth hormone receptor pathway interactions in preclinical models.
    • What is the recommended storage upon receipt?
      Store immediately at −20°C in a desiccated environment. For long-term stability, −80°C is preferred. Short-term at 2–8°C is acceptable. Inspect vials for integrity upon receipt.
    • What is a COA and why does it matter?
      A COA documents lot-specific results including purity (HPLC ≥98%), sequence verification (MS), and appearance. Each lot ships with a QR-accessible COA. Review before use to confirm identity and purity meet your experimental requirements.

  • PubMed Literature Search — 5-Amino-1MQ / NNMT inhibition
    Primary literature · curated search
    Open PubMed

    PubChem Compound Record Full chemical data, bioassays, patents
    View Record

    Source Document / Insert
    Supplier insert or supporting SDS source
    Download PDF

Additional information

Dosage

10mg

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