Description
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About Prostamax
Prostamax — a synthetic Ala-Glu-Asp-Lys tetrapeptide (CAS 135537-09-6) from the Khavinson peptide bioregulator series — is a tissue-specific peptide studied as a model prostate gland cytoprotective signal in urology and reproductive biology research. It is supplied as a laboratory-grade lyophilized powder intended strictly for analytical and non-clinical research applications.
As a member of the short peptide bioregulator family developed at the St. Petersburg Institute of Bioregulation and Gerontology, Prostamax is investigated for its selectivity toward prostate epithelial and stromal cell signaling models. Researchers use Prostamax in LNCaP, PC-3, DU145 prostate cell lines, and primary prostate epithelial models to examine effects on prostate-specific gene expression markers (PSA/KLK3, NKX3.1, FOXA1), smooth muscle/stromal signaling (α-SMA, TGF-β1 pathway), apoptosis/survival balance (Bcl-2/Bax, caspase-3 activity), and NF-κB-mediated inflammatory pathway regulation under standardized in vitro conditions.
COMMON RESEARCH APPLICATIONS
Prostate Epithelial Gene Expression Studies
Prostamax is examined in LNCaP and LAPC4 prostate cell models to study NKX3.1, FOXA1, and HOXB13 transcription factor expression, PSA/KLK3 androgen response element reporter activity, and prostate epithelial identity marker maintenance under challenge conditions.Prostatic Stromal Signaling & TGF-β Pathway Research
Used in primary prostate stromal fibroblast and WPMY-1 myofibroblast models to study TGF-β1/SMAD2/3 pathway activation, α-SMA expression, and collagen deposition as stromal remodeling pathway endpoint markers.NF-κB Inflammatory Pathway Modulation
Examined in PC-3 and DU145 prostate cell models under IL-6 and TNF-α cytokine challenge to characterize NF-κB p65 nuclear translocation, IL-8/CXCL1 secretion, and anti-inflammatory endpoint modulation.Comparative Khavinson Urological Peptide Screening
Benchmarked alongside related Khavinson tetrapeptides (Testagen, Pancragen) to characterize tissue-selective endocrine/epithelial signaling profiles and shared vs. distinct features within the prostate-targeted short peptide bioregulator class.Chemical Identity
Compound Name: Prostamax
Internal Catalog Code: Prostamax
CAS Number: 135537-09-6
Molecular Formula: C18H33N5O7
Molecular Weight: 435.48 g/mol
Physical Properties
Form/Appearance: Lyophilized powder
Quality & Testing
Purity: As listed on lot-specific COA
Testing Method : HPLC (as applicable) · identity confirmation per COA
Verification
COA: Lot-specific, included with order (QR on label)
Handling & Storage
Storage Temperature: Store desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.
Light Sensitivity: Protect from light
Moisture: Store desiccated when applicable
Available Strengths: 20 mg
SKU (20 mg): VE-PROS-020
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What is this product?
Prostamax (CAS 135537-09-6, MW 435.48 g/mol, C₁₈H₃₃N₅O₇) is a synthetic Ala-Glu-Asp-Lys tetrapeptide from the Khavinson bioregulator series, supplied as a lyophilized powder for laboratory research use only. It is studied as a model prostate gland cytoprotective peptide. Available as VE-PROS-020 (20 mg).
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What purity and testing methods are used?
Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity with sequence verification. A lot-specific COA is included with every order, accessible via QR code on the label.
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What are the key chemical identifiers?
CAS 135537-09-6 · Molecular formula C₁₈H₃₃N₅O₇ · MW 435.48 g/mol · Sequence: Ala-Glu-Asp-Lys · Synonyms: AEDK, Khavinson prostate peptide, prostate cytoprotective tetrapeptide
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What signaling pathways does Prostamax address in research models?
Prostamax is studied in prostate cell models for: prostate-specific transcription factor expression (NKX3.1, FOXA1, HOXB13), PSA/KLK3 expression under androgen receptor pathway conditions, TGF-β1/SMAD2/3 stromal signaling, NF-κB pathway modulation (IL-6, IL-8 cytokine expression), and androgen receptor (AR) target gene expression under standardized in vitro challenge conditions.
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How is Prostamax reconstituted for research use?
Dissolve in sterile water or PBS (pH 7.0) at ~5 mg/mL. Use immediately or aliquot and store at −80°C. Avoid repeated freeze-thaw cycles. Protect from light
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What is the recommended storage upon receipt?
Store immediately at −20°C desiccated. Short-term at 2–8°C acceptable for up to 2 weeks. Inspect vials for integrity upon receipt
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What is a COA and why does it matter?
A COA documents lot-specific purity (HPLC ≥98%), sequence verification (MS: Ala-Glu-Asp-Lys confirmed), and appearance. Each Prostamax lot ships with a QR-accessible COA. Review before use to confirm identity and purity meet your experimental requirements.
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