Pinealon

Pinealon

Price range: $36.00 through $110.00

Pinealon 5mg / 10mg / 20mg

What is PINE

Pinealon is supplied strictly for laboratory research and analytical applications, commonly referenced in cellular aging, regeneration, and redox pathway studies.

Specifications:
  • Strength: 2 mg per vial
  • Format: Lyophilized powder
  • Category: Cellular & Regulatory
  • Documentation: COA available

Research Use Only — Not for Human Consumption.

SKU: N/A Category:

Description

  • About Pinealon

    Pinealon is a tissue-specific peptide studied as a model pineal gland and neural cytoprotective signal in circadian biology and neuroprotection research. It is supplied as a laboratory-grade lyophilized powder intended strictly for analytical and non-clinical research applications.

    As a member of the short peptide bioregulator family developed at the St. Petersburg Institute of Bioregulation and Gerontology, Pinealon is the synthetic analog of the pineal gland-derived bioregulator peptide and is investigated alongside Epitalon for circadian and aging pathway research. Unlike Epitalon (which targets telomerase-related aging pathways), Pinealon s preclinical research focus is on direct neuroprotection and circadian gene regulation. Researchers use Pinealon in SH-SY5Y neuroblastoma, primary cortical neurons, and organotypic brain slice models to examine circadian gene expression (BMAL1, CLOCK, PER1/2/3), melatonin synthesis pathway markers (AANAT, HIOMT), BDNF/CREB neuroprotective signaling, and oxidative stress response (Nrf2/HO-1) under hypoxic or oxidative challenge conditions.

    COMMON RESEARCH APPLICATIONS

    Circadian Gene Regulation & Clock Biology
    Pinealon is examined in synchronized neuronal and pinealocyte models to study BMAL1/CLOCK/PER2/CRY1 expression dynamics, ROR-element (RORE) reporter activity, and circadian amplitude modulation as clock biology research endpoints.

    Neuroprotection Under Oxidative & Hypoxic Stress
    Used in SH-SY5Y, primary cortical neurons, and organotypic brain slice models under H₂O₂, rotenone, and OGD challenge to characterize BDNF/TrkB/CREB pathway activation, Nrf2/HO-1 antioxidant response, and cell viability outcomes.

    Melatonin Synthesis Pathway Studie
    Used in pinealocyte and AANAT-expressing cell models to study arylalkylamine N-acetyltransferase (AANAT) and HIOMT expression as pineal axis melatonin synthesis pathway markers, particularly in aging and light/dark cycle disruption models.

    Comparative Khavinson Neuro/Pineal Peptide Screening
    Benchmarked alongside Epitalon (Ala-Glu-Asp-Gly) and N-Acetyl Epitalon Amidate in pineal-axis and telomerase research; used to characterize distinct circadian vs. telomere pathway contributions and tissue-selective neuro/pineal signaling profiles.

  • Chemical Identity

    Compound Name: Pinealon

    Internal Catalog Code: Pinealon

    CAS Number: 135558-08-6

    Molecular Formula: C16H26N4O5

    Molecular Weight: 354.41 g/mol

    Physical Properties

    Form/Appearance: Lyophilized powder

    Quality & Testing

    Purity:

    Testing Method : HPLC (as applicable) · identity confirmation per COA

    Verification

    COA: Lot-specific, included with order (QR on label)

    Handling & Storage

    Storage Temperature: Store desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.

    Light Sensitivity: Protect from light

    Moisture: Store desiccated when applicable

    Available Strengths: 5 mg · 10 mg · 20 mg

    SKU (5 mg): VE-PINE-005

    SKU (10 mg): VE-PINE-010

    SKU (20 mg): VE-PINE-020

    • What is this product?
      Pinealon (CAS 135558-08-6, MW 354.41 g/mol, C₁₆H₂₆N₄O₅) is a synthetic Glu-Asp-Arg tripeptide from the Khavinson bioregulator series, supplied as a lyophilized powder for laboratory research use only. It is studied in circadian biology and neuroprotection research. Available as VE-PINE-005 (5 mg), VE-PINE-010 (10 mg), and VE-PINE-020 (20 mg).
    • What purity and testing methods are used?
      Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity with sequence verification. A lot-specific COA is included with every order, accessible via QR code on the label.
    • What are the key chemical identifiers?
      CAS 135558-08-6 · Molecular formula C₁₆H₂₆N₄O₅ · MW 354.41 g/mol · Sequence: Glu-Asp-Arg · Synonyms: EDR, Khavinson pineal peptide, pineal neuroprotective tripeptide, circadian bioregulator peptide.
    • What signaling pathways does Pinealon address in research models?
      Pinealon is studied in neural and pineal models for: circadian clock gene expression (BMAL1/CLOCK/PER2/CRY1 regulation), AANAT/HIOMT melatonin synthesis pathway markers, BDNF/TrkB/CREB neuroprotective signaling cascade, Nrf2/HO-1/NQO1 oxidative stress pathway in neurons, and mitochondrial membrane potential maintenance under ischemic/hypoxic challenge.
    • How is Pinealon reconstituted for research use?
      Dissolve in sterile water or PBS (pH 7.0) at ~5 mg/mL. Use immediately or aliquot and store at −80°C. Avoid repeated freeze-thaw cycles. Protect from light (the Trp-adjacent signaling context makes light-sensitivity relevant).
    • What is the recommended storage upon receipt?
      Store immediately at −20°C desiccated. Short-term at 2–8°C acceptable for up to 2 weeks. Inspect vials for integrity upon receipt.
    • What is a COA and why does it matter?
      A COA documents lot-specific purity (HPLC ≥98%), sequence verification (MS: Glu-Asp-Arg confirmed), and appearance. Each Pinealon lot ships with a QR-accessible COA. Review before use to confirm identity and purity meet your experimental requirements.

Additional information

Dosage

10mg, 20mg, 5mg

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