GHK-Cu
GHK-Cu - Image 2

GHK-Cu

$45.00

GHK-Cu | Copper Tripeptide Complex | CAS 49557-75-7

Cellular Repair & Copper Peptide Research

GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper) is a synthetic copper-binding
tripeptide commonly referenced in extracellular matrix research, cellular
signaling studies, peptide regulation, and tissue pathway analysis.

In plain terms: GHK-Cu is used in laboratory models to see how copper-bound peptides signal cells to build collagen and fix damaged skin or connective tissues.

  • 50 mg lyophilized powder
  • ≥98% purity by HPLC analysis
  • Lot-specific COA and laboratory documentation available

Research Use Only — Not for Human Consumption.

SKU: VE-GHKCU-050 Category:

Description

  • About GHK-Cu (Copper Peptide GHK-Cu)

    GHK-Cu — glycyl-L-histidyl-L-lysine copper(II) complex (CAS 89030-95-5) — is a naturally occurring plasma tripeptide that forms a stable complex with copper(II) ions. It is one of the most studied peptide-metal complexes for wound healing, collagen remodeling, and skin biology research. Endogenous GHK-Cu levels decline sharply with age (from ~200 ng/mL in young adults to ~80 ng/mL in older adults), making it a well-characterized age-associated biomarker in aging biology research.

    GHK-Cu activates a broad range of wound healing and anti-inflammatory genes via interaction with DNA-binding proteins and has been shown to upregulate collagen, fibronectin, and decorin synthesis in fibroblast models. Supplied as lyophilized powder for analytical and non-clinical research use only.

    COMMON RESEARCH APPLICATIONS

    Collagen Synthesis & Remodeling
    GHK-Cu stimulates collagen type I and III synthesis and upregulates MMP-2 in dermal fibroblast models. Used in collagen gel contraction assays and gene expression studies examining TGF-β-independent collagen remodeling pathways.

    Wound Healing Pathway Research
    Activates wound response genes including fibronectin, decorin, and osteopontin. Used in scratch assay and 3D skin equivalent models to study growth factor-like signaling without receptor tyrosine kinase activation.

    Anti-Inflammatory Gene Expression
    Suppresses TNF-α, IL-6, and IL-1β expression in macrophage models. Used to study NF-κB pathway modulation and anti-oxidant gene upregulation (SOD, catalase) in inflammatory challenge models.

    Aging Biology & Senescence Research
    Used as an age-associated peptide marker in cell aging models; studied for effects on p53/p63 signaling, telomere maintenance, and DNA repair gene upregulation in senescent fibroblasts.

  • Chemical Identity

    Compound Name: GHK-Cu

    Synonyms: Copper peptide GHK · GHK-copper · glycyl-l-histidyl-l-lysine copper(II) · Lamin · Iamin

    CAS Number: 49557-75-7 (GHK free base); 89030-95-5 (GHK-Cu complex)

    EC Number: N/A (peptide-metal complex)

    Molecular Formula: C₁₄H₂₃CuN₆O₄

    Molecular Weight: 462.00 g/mol

    Physical Properties

    Appearance: Blue to blue-green lyophilized powder

    Solubility (water): ≥10 mg/mL in sterile water (pH 6–7)

    Solubility (organic): Limited in ethanol; insoluble in DMSO

    Hygroscopic: Yes — store desiccated

    Quality & Testing

    Purity: ≥98% (HPLC)

    Testing Method : Reverse-phase HPLC · ICP-MS copper content verification · sequence confirmation

    Verification

    COA: Lot-specific, included with order (QR on label)

    SDS Supplier : See SDS/MSDS · OSHA HCS / GHS compliant

    Handling & Storage

    Storage Temperature: Store desiccated at −20°C long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.

    Light Sensitivity: Protect from light

    Reconstitution: Dissolve in sterile water at ≥10 mg/mL; stable at neutral pH; precipitates at alkaline pH

    Available Strengths: 50 mg · 100 mg

    SKU (50 mg): VE-GHKCU-050

    SKU (100 mg): VE-GHKCU-100

    • What is this product?
      GHK-Cu is supplied as a lyophilized copper peptide complex (CAS 89030-95-5, MW 462.00 g/mol) intended for laboratory research use only. It is a naturally occurring tripeptide-copper(II) complex found in human plasma, urine, and saliva.
    • What purity and testing methods are used?
      Each lot is tested by reverse-phase HPLC to ≥98% purity with ICP-MS copper content verification and sequence confirmation. A lot-specific COA is included with every order, accessible via QR code on the label.
    • What are the key chemical identifiers?
      CAS 89030-95-5 (GHK-Cu complex); 49557-75-7 (GHK free peptide) · Molecular formula C₁₄H₂₃CuN₆O₄ · MW 462.00 g/mol · Synonyms: copper peptide GHK, glycyl-l-histidyl-l-lysine copper(II), Lamin.
    • What research pathways does GHK-Cu affect?
      GHK-Cu has been studied for upregulation of collagen I/III, fibronectin, and decorin in fibroblasts; TNF-α/IL-6 suppression in macrophage models; and activation of SOD and catalase antioxidant pathways. It also interacts with DNA-binding proteins involved in wound response gene networks.
    • What is the recommended storage upon receipt?
      Store immediately at −20°C desiccated. The copper complex is sensitive to moisture and light. Short-term at 2–8°C is acceptable. Inspect vials for color integrity (should be blue to blue-green) upon receipt.
    • What is a COA and why does it matter?
      A COA documents lot-specific purity (HPLC ≥98%), copper content (ICP-MS), sequence confirmation, and appearance. Each lot ships with a QR-accessible COA. Review before use to confirm identity, purity, and copper stoichiometry meet your experimental requirements.

  • PubMed Literature Search — GHK-Cu
    Primary literature · 400+ indexed studies
    Open PubMed

    PubChem Compound Record
    CAS 300801-03-0 · Full chemical data, bioassays, patents
    View Record

    Supplier Product Insert / Technical Data Sheet
    Solubility data, copper content verification, storage protocol
    Download PDF

Additional information

Dosage

100mg, 50mg

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