Cortagen

Cortagen

$102.00

Cortagen | Neuroregulatory Peptide Compound

Neuronal Signaling & Cognitive Research

Cortagen is a synthetic bioregulatory peptide compound commonly referenced in
neuronal signaling, neuropeptide pathway analysis, cognitive research models,
and cellular communication studies.

In plain terms: Cortagen is studied in laboratory settings examining how
short-chain peptide bioregulators interact with neuronal tissue signaling
pathways and neuroregulatory cellular mechanisms.

  • 20 mg lyophilized powder
  • ≥98% purity by HPLC analysis where applicable
  • Lot-specific COA and laboratory documentation available

Research Use Only — Not for Human Consumption.

Available on backorder

SKU: VE-CORT-020 Category:

Description

  • About Cortagen

    Cortagen — a synthetic Ala-Glu-Asp-Pro tetrapeptide (CAS 135537-12-1) from the Khavinson peptide bioregulator series — is a tissue-specific peptide studied as a model cerebrocortical and neural cytoprotective signal in neuroscience and neuroprotection research. It is supplied as a laboratory-grade lyophilized powder intended strictly for analytical and non-clinical research applications.

    As a member of the short peptide bioregulator family, Cortagen is investigated for its selectivity toward cortical neuron and neural tissue signalling models. Researchers use Cortagen in primary cortical neuron cultures, SH-SY5Y neuroblastoma, and HT22 hippocampal cell models to examine effects on neuronal cell survival pathway activation (BDNF, CREB signalling), oxidative stress response (Nrf2/HO-1 pathway), and neuroprotective gene expression markers under excitotoxic, oxidative, or hypoxic challenge conditions.

    COMMON RESEARCH APPLICATIONS

    Cortical Neuron Survival & Neuroprotection Research
    Cortagen is examined in primary cortical neuron and SH-SY5Y models under glutamate excitotoxicity or H₂O₂ oxidative challenge to study CREB phosphorylation, BDNF expression, caspase-3 activity, and MAP2 cytoskeletal integrity as neuroprotective endpoint markers.

    Nrf2 / HO-1 Oxidative Stress Pathway Studies
    Used in neuronal and astrocyte cell models under oxidative challenge (H₂O₂, 6-OHDA) to characterise Nrf2 nuclear translocation, HO-1 and NQO1 expression, and GSH/GSSG ratio modulation as antioxidant pathway endpoints.

    BDNF / Neurotrophin Signalling Research
    Examined in cortical neuron and hippocampal cell lines to study TrkB receptor pathway activation, ERK1/2 phosphorylation, and downstream CREB/BDNF signalling in models of synaptic plasticity and neural circuit maintenance.

    Comparative Khavinson Neuropeptide Screening
    Benchmarked alongside Pinealon and other neural-targeted Khavinson tetrapeptides to characterise CNS tissue selectivity, stress response pathway overlap, and differential neuroprotective signalling profiles.

  • Chemical Identity

    Compound Name: Cortagen

    Synonyms: Ala-Glu-Asp-Pro · Khavinson neural peptide · cortex cytoprotective tetrapeptide

    CAS Number: 135537-12-1

    EC Number: N/A (synthetic tetrapeptide)

    Molecular Formula: C16H30N6O6 (note: Pro-containing tetrapeptide; verify MW against current COA)

    Molecular Weight: 390.45 g/mol

    Physical Properties

    Appearance: White to off-white lyophilized powder

    Solubility (water): ~5 mg/mL in sterile water or PBS (pH 7.0)

    Solubility (organic): Limited solubility in organic solvents

    Hygroscopic: Yes — store desiccated

    Quality & Testing

    Purity: ≥98% (HPLC)

    Testing Method : Reverse-phase HPLC · MS confirmation · sequence verification

    Verification

    COA: Lot-specific, included with order (QR on label)

    SDS Supplier : Velox Research Chemicals

    SDS Revision: Current lot · OSHA HCS / GHS compliant

    Handling & Storage

    Storage Temperature: Store desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.

    Light Sensitivity: Protect from light

    Reconstitution: Dissolve in sterile water or PBS (pH 7.0); use immediately or aliquot and store at −80°C

    Available Strengths: 20 mg

    SKU (20 mg): VE-CORT-020

    • What is this product?
      Cortagen (CAS 135537-12-1, MW 390.45 g/mol) is a synthetic Ala-Glu-Asp-Pro tetrapeptide from the Khavinson bioregulator series, supplied as a lyophilized powder for laboratory research use only. It is studied as a model cerebrocortical cytoprotective peptide in neuronal signalling and neuroprotection research.
    • What purity and testing methods are used?
      Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity with sequence verification. A lot-specific COA is included with every order, accessible via QR code on the label.
    • What are the key chemical identifiers?
      CAS 135537-12-1 · Molecular formula C₁₆H₃₀N₆O₆ · MW 390.45 g/mol · Sequence: Ala-Glu-Asp-Pro · Synonyms: Khavinson neural peptide, cortex cytoprotective tetrapeptide.
    • How is Cortagen reconstituted for research use?
      Dissolve in sterile water or PBS (pH 7.0) at ~5 mg/mL. Use immediately or aliquot and store at −80°C. Avoid repeated freeze-thaw cycles. Protect from light.
    • What is the recommended storage upon receipt?
      Store immediately at −20°C desiccated. Short-term at 2–8°C is acceptable for up to 2 weeks. Inspect vials for integrity upon receipt.
    • What is a COA and why does it matter?
      A COA documents lot-specific purity (HPLC ≥98%), sequence verification (MS), and appearance. Each lot ships with a QR-accessible COA. Review before use to confirm identity and purity meet your experimental requirements.

  • PubMed Literature Search — Cortagen
    Primary literature · curated search
    Open PubMed

    PubMed Literature Search — Cortagen (Русский)
    Includes Cyrillic term: Кортаген
    Open PubMed

    PubChem Compound Record
    Full chemical data, bioassays, patents
    View Record

    Source Document / Insert
    Supplier insert or supporting SDS source
    Download PDF

Related products