Description
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About Cortagen
Cortagen — a synthetic Ala-Glu-Asp-Pro tetrapeptide (CAS 135537-12-1) from the Khavinson peptide bioregulator series — is a tissue-specific peptide studied as a model cerebrocortical and neural cytoprotective signal in neuroscience and neuroprotection research. It is supplied as a laboratory-grade lyophilized powder intended strictly for analytical and non-clinical research applications.
As a member of the short peptide bioregulator family, Cortagen is investigated for its selectivity toward cortical neuron and neural tissue signalling models. Researchers use Cortagen in primary cortical neuron cultures, SH-SY5Y neuroblastoma, and HT22 hippocampal cell models to examine effects on neuronal cell survival pathway activation (BDNF, CREB signalling), oxidative stress response (Nrf2/HO-1 pathway), and neuroprotective gene expression markers under excitotoxic, oxidative, or hypoxic challenge conditions.
COMMON RESEARCH APPLICATIONS
Cortical Neuron Survival & Neuroprotection Research
Cortagen is examined in primary cortical neuron and SH-SY5Y models under glutamate excitotoxicity or H₂O₂ oxidative challenge to study CREB phosphorylation, BDNF expression, caspase-3 activity, and MAP2 cytoskeletal integrity as neuroprotective endpoint markers.Nrf2 / HO-1 Oxidative Stress Pathway Studies
Used in neuronal and astrocyte cell models under oxidative challenge (H₂O₂, 6-OHDA) to characterise Nrf2 nuclear translocation, HO-1 and NQO1 expression, and GSH/GSSG ratio modulation as antioxidant pathway endpoints.BDNF / Neurotrophin Signalling Research
Examined in cortical neuron and hippocampal cell lines to study TrkB receptor pathway activation, ERK1/2 phosphorylation, and downstream CREB/BDNF signalling in models of synaptic plasticity and neural circuit maintenance.Comparative Khavinson Neuropeptide Screening
Benchmarked alongside Pinealon and other neural-targeted Khavinson tetrapeptides to characterise CNS tissue selectivity, stress response pathway overlap, and differential neuroprotective signalling profiles. -
Chemical Identity
Compound Name: Cortagen
Synonyms: Ala-Glu-Asp-Pro · Khavinson neural peptide · cortex cytoprotective tetrapeptide
CAS Number: 135537-12-1
EC Number: N/A (synthetic tetrapeptide)
Molecular Formula: C16H30N6O6 (note: Pro-containing tetrapeptide; verify MW against current COA)
Molecular Weight: 390.45 g/mol
Physical Properties
Appearance: White to off-white lyophilized powder
Solubility (water): ~5 mg/mL in sterile water or PBS (pH 7.0)
Solubility (organic): Limited solubility in organic solvents
Hygroscopic: Yes — store desiccated
Quality & Testing
Purity: ≥98% (HPLC)
Testing Method : Reverse-phase HPLC · MS confirmation · sequence verification
Verification
COA: Lot-specific, included with order (QR on label)
SDS Supplier : Velox Research Chemicals
SDS Revision: Current lot · OSHA HCS / GHS compliant
Handling & Storage
Storage Temperature: Store desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.
Light Sensitivity: Protect from light
Reconstitution: Dissolve in sterile water or PBS (pH 7.0); use immediately or aliquot and store at −80°C
Available Strengths: 20 mg
SKU (20 mg): VE-CORT-020
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What is this product?
Cortagen (CAS 135537-12-1, MW 390.45 g/mol) is a synthetic Ala-Glu-Asp-Pro tetrapeptide from the Khavinson bioregulator series, supplied as a lyophilized powder for laboratory research use only. It is studied as a model cerebrocortical cytoprotective peptide in neuronal signalling and neuroprotection research.
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What purity and testing methods are used?
Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity with sequence verification. A lot-specific COA is included with every order, accessible via QR code on the label.
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What are the key chemical identifiers?
CAS 135537-12-1 · Molecular formula C₁₆H₃₀N₆O₆ · MW 390.45 g/mol · Sequence: Ala-Glu-Asp-Pro · Synonyms: Khavinson neural peptide, cortex cytoprotective tetrapeptide.
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How is Cortagen reconstituted for research use?
Dissolve in sterile water or PBS (pH 7.0) at ~5 mg/mL. Use immediately or aliquot and store at −80°C. Avoid repeated freeze-thaw cycles. Protect from light.
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What is the recommended storage upon receipt?
Store immediately at −20°C desiccated. Short-term at 2–8°C is acceptable for up to 2 weeks. Inspect vials for integrity upon receipt.
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What is a COA and why does it matter?
A COA documents lot-specific purity (HPLC ≥98%), sequence verification (MS), and appearance. Each lot ships with a QR-accessible COA. Review before use to confirm identity and purity meet your experimental requirements.
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What is this product?
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