Description
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About CJC-1295 + Ipamorelin
CJC-1295 + Ipamorelin is a dual-peptide research blend combining CJC-1295 (No DAC, Mod GRF(1-29), CAS 446036-97-1) and Ipamorelin (NNC 26-0161, CAS 170851-70-4) for controlled laboratory study of synergistic growth hormone axis signaling. It is supplied as a lyophilized powder intended strictly for analytical and non-clinical research applications.
CJC-1295 (No DAC) is a stabilised GHRH analogue that activates the GHRH receptor (GHRHR) on pituitary somatotroph cells, stimulating GH synthesis and release. Ipamorelin is a selective GHSR-1a agonist (ghrelin receptor) that triggers GH release via a mechanistically distinct pathway — without significantly co-elevating cortisol or ACTH, a key selectivity advantage over earlier GHRPs. The combination is used in pituitary cell and hypothalamic-pituitary axis research models to study dual-receptor GH axis activation, somatotroph signalling amplification, and downstream IGF-1 pathway mapping.
COMMON RESEARCH APPLICATIONS
Dual-Receptor GH Axis Activation Studies
Used in GH3 pituitary cell and primary somatotroph models to examine simultaneous GHRHR agonism (CJC-1295) and GHSR-1a agonism (Ipamorelin), quantifying additive or synergistic effects on GH secretion, cAMP accumulation, and MAPK pathway activation.IGF-1 Pathway Mapping
Examined in hepatocyte and skeletal muscle cell lines under conditioned GH stimulation to study STAT5b phosphorylation, IGF-1 gene expression, and downstream IGF-1R/AKT/mTOR pathway activity downstream of combinatorial GHRH+GHRP stimulation.GH Pulse & Secretion Kinetics Research
Used in time-course secretion experiments with GH ELISA readouts to characterize pulse amplitude, duration, and inter-pulse interval under dual-pathway stimulation vs. each peptide alone, studying pulsatile GH signalling dynamics in vitro.Comparative GHRH/GHRP Blend Screening
Benchmarked against CJC-1295 (No DAC) alone, Ipamorelin alone, and other GHRH/GHRP combinations (e.g., Sermorelin + GHRP-6) to characterise receptor pathway selectivity and signal amplification profiles across GH axis research models. -
Chemical Identity
Compound Name: CJC-1295 (No DAC) + Ipamorelin blend
Synonyms: Mod GRF(1-29) / NNC 26-0161 research blend · GHRH analog + GHRP co-treatment blend
CAS Number: 446036-97-1 (CJC-1295 No DAC) · 170851-70-4 (Ipamorelin)
EC Number: N/A (synthetic peptide blend)
Molecular Formula: C152H252N44O42 (CJC-1295 No DAC) · C38H49N9O5 (Ipamorelin)
Molecular Weight: 3367.90 g/mol (CJC-1295 No DAC) · 711.90 g/mol (Ipamorelin)
Physical Properties
Appearance: White to off-white lyophilized powder blend
Solubility (water): ~2 mg/mL in sterile water or PBS (pH 7.0)
Solubility (organic): Limited solubility in organic solvents
Hygroscopic: Yes — store desiccated
Quality & Testing
Purity: ≥98% each component (HPLC)
Testing Method : Reverse-phase HPLC · MS confirmation · sequence verification per component
Verification
COA: Lot-specific, included with order (QR on label)
SDS Supplier : Velox Research Chemicals
SDS Revision: Current lot · OSHA HCS / GHS compliant
Handling & Storage
Storage Temperature: Store desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.
Light Sensitivity: Protect from light
Reconstitution: Dissolve in sterile water or PBS (pH 7.0); use immediately or aliquot and store at −80°C
Available Strengths: 5 mg blend
SKU (5 mg): VE-CJCND-IPA-BLEND
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What is this product?
CJC-1295 + Ipamorelin is a lyophilized research blend of CJC-1295 No DAC (CAS 446036-97-1, MW 3367.90 g/mol) and Ipamorelin (CAS 170851-70-4, MW 711.90 g/mol) for controlled laboratory study of dual-receptor growth hormone axis signalling. For research use only.
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What purity and testing methods are used?
Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity per component with sequence verification for each peptide. A lot-specific COA is included with every order, accessible via QR code on the label.
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What are the key chemical identifiers for each component?
CJC-1295 No DAC: CAS 446036-97-1 · MW 3367.90 g/mol · also known as Mod GRF(1-29). Ipamorelin: CAS 170851-70-4 · C₃₈H₄₉N₉O₅ · MW 711.90 g/mol · also known as NNC 26-0161.
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How is this blend reconstituted for research use?
Dissolve in sterile water or PBS (pH 7.0) at ~2 mg/mL. Use immediately or aliquot and store at −80°C. Avoid repeated freeze-thaw cycles. Protect from light.
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What is the recommended storage upon receipt?
A COA documents lot-specific purity per component (HPLC ≥98%), sequence verification (MS), and appearance. Each lot ships with a QR-accessible COA. Review before use to confirm both peptides meet your experimental requirements.
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What is a COA and why does it matter?
A COA documents lot-specific purity (HPLC ≥98%), sequence verification (MS), and appearance. Each lot ships with a QR-accessible COA. Review before use to confirm identity and purity meet your experimental requirements.
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What is this product?




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