Description
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About Cartalax
Cartalax — a synthetic Ala-Glu-Asp-Gly tetrapeptide (CAS 135537-10-9) from the Khavinson peptide bioregulator series — is a tissue-specific peptide studied as a model chondrocyte and cartilage signalling tool in musculoskeletal and ECM research. It is supplied as a laboratory-grade lyophilized powder intended strictly for analytical and non-clinical research applications.
As a member of the short peptide bioregulator family, Cartalax is investigated for its selectivity toward cartilage and connective tissue signalling models. Researchers use Cartalax in primary chondrocyte, ATDC5, and C28/I2 chondrocyte cell line models to examine effects on cartilage ECM synthesis pathways (aggrecan, type II collagen expression), MMP-mediated ECM degradation signalling (MMP-3, MMP-13, ADAMTS activity), and chondrocyte apoptosis and differentiation markers under standardised in vitro and ex vivo conditions.
COMMON RESEARCH APPLICATIONS
Cartilage ECM Synthesis Pathway Research
Cartalax is examined in primary chondrocyte and ATDC5 models to study type II collagen and aggrecan gene expression, SOX9 transcription factor activity, and pro-collagen processing pathway markers under baseline and cytokine-challenged (IL-1β, TNF-α) conditions.MMP-Mediated ECM Degradation Signalling
Used in chondrocyte models under catabolic challenge to study MMP-3/MMP-13 expression modulation, ADAMTS-4/5 activity, and tissue inhibitor of metalloproteinase (TIMP-1/3) balance as key ECM remodelling endpoints.Chondrocyte Apoptosis & Differentiation Studies
Examined in hypoxia, ROS-challenge, and mechanical stress chondrocyte models to assess caspase-3 activity, Bcl-2/Bax ratio, and chondrogenic differentiation marker expression (SOX9, COL2A1) as cytoprotective pathway endpoints.Comparative Khavinson Musculoskeletal Peptide Screening
Benchmarked alongside Testagen, Prostamax, and other Khavinson tetrapeptides to characterise tissue selectivity and shared vs. distinct signalling features, particularly in ECM remodelling and chondrocyte biology models. -
Chemical Identity
Compound Name: Cartalax
Synonyms: Ala-Glu-Asp-Gly · Khavinson cartilage peptide · chondrocyte cytoprotective tetrapeptide
CAS Number: 135537-10-9
EC Number: N/A (synthetic tetrapeptide)
Molecular Formula: C11H20N4O7 (note: some literature records variable hydration states)
Molecular Weight: 324.31 g/mol
Physical Properties
Appearance: White to off-white lyophilized powder
Solubility (water): ~5 mg/mL in sterile water or PBS (pH 7.0)
Solubility (organic): Limited solubility in organic solvents
Hygroscopic: Yes — store desiccated
Quality & Testing
Purity: ≥98% (HPLC)
Testing Method : Reverse-phase HPLC · MS confirmation · sequence verification
Verification
COA: Lot-specific, included with order (QR on label)
SDS Supplier : Velox Research Chemicals
SDS Revision: Current lot · OSHA HCS / GHS compliant
Handling & Storage
Storage Temperature: Store desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.
Light Sensitivity: Protect from light
Reconstitution: Dissolve in sterile water or PBS (pH 7.0); use immediately or aliquot and store at −80°C
Available Strengths: 20 mg
SKU (20 mg): VE-CART-020
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What is this product?
Cartalax (CAS 135537-10-9, MW 324.31 g/mol) is a synthetic Ala-Glu-Asp-Gly tetrapeptide from the Khavinson bioregulator peptide series, supplied as a lyophilized powder for laboratory research use only. It is studied as a model chondrocyte and cartilage ECM signalling peptide.
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What purity and testing methods are used?
Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity with sequence verification. A lot-specific COA is included with every order, accessible via QR code on the label.
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What are the key chemical identifiers?
CAS 135537-10-9 · Molecular formula C₁₁H₂₀N₄O₇ · MW 324.31 g/mol · Sequence: Ala-Glu-Asp-Gly · Synonyms: Khavinson cartilage peptide, chondrocyte cytoprotective tetrapeptide.
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How is Cartalax reconstituted for research use?
Dissolve in sterile water or PBS (pH 7.0) at ~5 mg/mL. Use immediately or aliquot and store at −80°C. Avoid repeated freeze-thaw cycles. Protect from light.
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What is the recommended storage upon receipt?
Store immediately at −20°C desiccated. Short-term at 2–8°C is acceptable for up to 2 weeks. Inspect vials for integrity upon receipt.
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What is a COA and why does it matter?
A COA documents lot-specific purity (HPLC ≥98%), sequence verification (MS), and appearance. Each lot ships with a QR-accessible COA. Review before use to confirm identity and purity meet your experimental requirements.
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What is this product?
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