Description
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About AOD-9604 + L-Carnitine
AOD-9604 + L-Carnitine is a dual-component research blend combining AOD-9604 (hGH fragment 176–191, CAS 221231-10-3) and L-Carnitine (CAS 541-15-1) for controlled laboratory investigation of complementary fat metabolism signaling pathways. It is supplied as a lyophilized powder intended strictly for analytical and non-clinical research applications.
The formulation targets two mechanistically distinct nodes of lipid metabolism: AOD-9604 engages the lipolysis axis via β3-adrenergic receptor/HSL pathway activation in adipocytes, while L-Carnitine is studied for its role in the carnitine shuttle system governing long-chain fatty acid transport across the inner mitochondrial membrane. Researchers use this blend in 3T3-L1 adipocyte, hepatocyte, and muscle cell models to study multi-pathway lipid flux, mitochondrial β-oxidation capacity, and comparative metabolic substrate utilization under standardized assay conditions.
COMMON RESEARCH APPLICATIONS
Multi-Pathway Lipolysis & β-Oxidation Research
Used in 3T3-L1 and primary adipocyte models to simultaneously examine AOD-9604-driven HSL pathway activation alongside L-Carnitine-mediated CPT1/CPT2 flux, quantifying additive effects on free fatty acid release and mitochondrial oxidation rates.Adipocyte Biology & Body Composition Signaling
Studied in differentiated adipocyte models measuring lipid droplet dynamics, perilipin phosphorylation, and ATGL activity under controlled co-treatment conditions to characterize cooperative lipolysis signaling.Metabolic Substrate Utilization Studies
Used in Seahorse XF assays and oxygen consumption rate (OCR) experiments to assess whether combined AOD-9604 / L-Carnitine treatment alters mitochondrial fuel preference (fatty acid vs. glucose oxidation) in muscle and liver cell lines.Comparative Blend vs. Monotherapy Screening
Benchmarked against AOD-9604 alone and L-Carnitine alone to evaluate pathway selectivity, kinetics, and whether blending confers complementary or additive activity in metabolic pathway assays. -
Chemical Identity
Compound Name: AOD-9604 + L-Carnitine blend
Synonyms: hGH(176–191) / L-Carnitine research blend · AOD9604 + L-Carnitine
CAS Number: 221231-10-3 (AOD-9604) · 541-15-1 (L-Carnitine)
EC Number: N/A (synthetic peptide blend)
Molecular Formula: C78H123N23O23S2 (AOD-9604) · C7H15NO3 (L-Carnitine)
Molecular Weight: 1815.08 g/mol (AOD-9604) · 161.20 g/mol (L-Carnitine)
Physical Properties
Appearance: White to off-white lyophilized powder blend
Solubility (water): ~2 mg/mL in sterile water or PBS (pH 7.4)
Solubility (organic): Limited; consult SDS per component
Hygroscopic: Yes — store desiccated
Quality & Testing
Purity: ≥98% each component (HPLC)
Testing Method : Reverse-phase HPLC · MS confirmation · component ratio
Verification
COA: Lot-specific, included with order (QR on label)
SDS Supplier : Velox Research Chemicals
SDS Revision: Current lot · OSHA HCS / GHS compliant
Handling & Storage
Storage Temperature: SStore desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.
Light Sensitivity: Protect from light
Reconstitution: Dissolve in sterile water or PBS (pH 7.4); use immediately or aliquot and store at −80°C
Available Strengths: 10 mg blend
SKU (10 mg): VE-AOD-LCAR-BLEND
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What is this product?
AOD-9604 + L-Carnitine is a lyophilized research blend of AOD-9604 (CAS 221231-10-3, MW 1815.08 g/mol) and L-Carnitine (CAS 541-15-1, MW 161.20 g/mol) for controlled laboratory study of complementary fat metabolism signaling. For research use only.
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What purity and testing methods are used?
Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity per component, with blend ratio verification. A lot-specific COA is included with every order, accessible via QR code on the label.
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What are the key chemical identifiers for each component?
AOD-9604: CAS 221231-10-3 · C₇₈H₁₂₃N₂₃O₂₃S₂ · MW 1815.08 g/mol. L-Carnitine: CAS 541-15-1 · C₇H₁₅NO₃ · MW 161.20 g/mol.
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Why combine AOD-9604 with L-Carnitine in a research model?
The blend targets two mechanistically distinct nodes: AOD-9604 activates the lipolysis axis (β3-AR/HSL pathway) to mobilize stored fatty acids, while L-Carnitine facilitates mitochondrial fatty acid transport (CPT1/CPT2 carnitine shuttle). Together they allow multi-pathway fat metabolism research under a single experimental condition.
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What is the recommended storage upon receipt?
Store immediately at −20°C desiccated. Short-term at 2–8°C is acceptable for up to 2 weeks. Inspect vials for integrity upon receipt.
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What is a COA and why does it matter?
A COA documents lot-specific purity per component (HPLC ≥98%), identity (MS), blend ratio, and appearance. Each lot ships with a QR-accessible COA. Review before use to confirm both components meet your experimental requirements.
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