Description
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About NA Selank amidate
N-Acetyl Selank Amidate (CAS 2212313-10-6) is a doubly-stabilized synthetic derivative of Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro, TP-7) incorporating N-terminal acetylation and C-terminal amidation, which significantly enhances proteolytic stability and blood-brain barrier (BBB) penetration compared to the unmodified heptapeptide. It is supplied as a laboratory-grade lyophilized powder intended strictly for analytical and non-clinical research applications.
Selank is a tuftsin-derived heptapeptide originally developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. The N-acetyl and C-amide modifications shield both termini from exopeptidase cleavage, extending half-life while preserving the core TKPRPGP pharmacophore. N-Acetyl Selank Amidate has been characterized for GABA-A receptor positive allosteric modulation, BDNF/TrkB upregulation in hippocampal cell models, IL-6 cytokine modulation, and enkephalin degradation inhibition. Researchers use this compound in SH-SY5Y, primary cortical neuron, and immune cell models as a stabilized probe for GABAergic anxiolytic signaling, neurotrophic factor regulation, and comparative pharmacological studies against unmodified Selank.
COMMON RESEARCH APPLICATIONS
GABAergic Signaling & Anxiolytic Pathway Research
N-Acetyl Selank Amidate is examined in primary cortical neuron and SH-SY5Y models to study GABA-A receptor positive allosteric modulation, Cl⁻ channel kinetics, and GABA-A subunit expression changes as anxiolytic pathway endpoint markers.BDNF/TrkB Neuroprotection Studies
Used in hippocampal and cortical neuron models under glutamate excitotoxicity or oxidative challenge to characterize BDNF expression, TrkB phosphorylation, CREB activation, and downstream neuroprotective gene expression vs. unmodified Selank.Enkephalin Stability & Neuropeptide Degradation Assays
Used in brain homogenate and plasma peptidase assays to compare Selank vs. N-Acetyl Selank Amidate half-life, enzymolytic degradation kinetics, and neprilysin/aminopeptidase-N inhibition potency as a function of terminal modification.Comparative Selank Form Benchmarking
Reference stabilized form for paired studies alongside unmodified Selank to characterize the pharmacological contribution of N-acetylation and C-terminal amidation on GABA-A potentiation, BDNF upregulation, BBB penetration estimates, and neuroimmune IL-6 modulation. -
Chemical Identity
Compound Name: NA Selank amidate
Internal Catalog Code: NA Selank amidate
CAS Number: 2212313-10-6
Molecular Formula: C₃₅H₅₉N₁₁O₁₀
Molecular Weight: 793.92 g/mol
Physical Properties
Form/Appearance: Lyophilized powder
Quality & Testing
Purity: As listed on lot-specific COA
Testing Method : HPLC (as applicable) · identity confirmation per COA
Verification
COA: Lot-specific, included with order (QR on label)
Handling & Storage
Storage Temperature: Store desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.
Light Sensitivity: Protect from light
Moisture: Store desiccated when applicable
Available Strengths: 30 mg
SKU (30 mg): VE-NASE-030
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What is this product?
N-Acetyl Selank Amidate (CAS 2212313-10-6, MW 793.92 g/mol, C₃₅H₅₉N₁₁O₁₀) is supplied as a lyophilized doubly-stabilized Selank derivative (Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-NH₂) for laboratory research use only. Available as VE-NASE-030 (30 mg).
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What purity and testing methods are used?
Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity with sequence and modification verification (N-Ac and C-amide confirmed). A lot-specific COA is included with every order, accessible via QR code on the label.
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What are the key chemical identifiers?
CAS 2212313-10-6 · Molecular formula C₃₅H₅₉N₁₁O₁₀ · MW 793.92 g/mol · Sequence: Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-NH₂ · Synonyms: N-Ac Selank amidate, acetylated-amidated Selank, stabilized TP-7.
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How does N-Acetyl Selank Amidate differ from standard Selank in research use?
Unmodified Selank (CAS 129954-34-3) has a short half-life due to exopeptidase cleavage at the N- and C-termini. N-Acetyl Selank Amidate extends half-life through dual terminal protection, and the C-terminal amide improves membrane permeability and BBB penetration. For acute signaling studies or pharmacokinetic comparisons where short exposure is desired, unmodified Selank is preferred. For sustained signal studies or models requiring extended receptor engagement, the amidate form is preferred.
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How is N-Acetyl Selank Amidate reconstituted for research use?
Dissolve in sterile water or PBS (pH 7.0) at ~5 mg/mL. Alternatively, dissolve in DMSO (~2 mg/mL) for organic solvent applications. Aliquot and store at −20°C. Avoid repeated freeze-thaw. Protect from light.
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What is the recommended storage upon receipt?
Store immediately at −20°C desiccated. Short-term at 2–8°C acceptable for up to 2 weeks of active use. Inspect vials for integrity upon receipt.
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What is a COA and why does it matter?
A COA documents lot-specific purity (HPLC ≥98%), MS identity, and modification verification (N-acetyl and C-amide). For modified peptides, confirming both terminal modifications are present is essential — incomplete modification produces a heterogeneous sample. Each lot ships with a QR-accessible COA. Review before use.
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