Ovagen

Ovagen

$99.99

Ovagen 20 mg

What is OVAG

Ovagen (20 mg) is supplied strictly for laboratory research and analytical applications, commonly referenced in endocrine axis, organ-signaling, and regulatory pathway studies.

Specifications:
  • Strength: 20 mg per vial
  • Format: Lyophilized powder
  • Category: Cellular & Regulatory Signaling
  • Documentation: COA available

Research Use Only — Not for Human Consumption.

1000 in stock

SKU: VE-OVAG-020 Category:

Description

  • About Ovagen

    Ovagen — a synthetic Ile-Glu-Asp-Glu tetrapeptide (CAS 135537-14-3) from the Khavinson peptide bioregulator series — is a tissue-specific peptide studied as a model hepatic and liver cytoprotective signal in liver biology and detoxification research. It is supplied as a laboratory-grade lyophilized powder intended strictly for analytical and non-clinical research applications.

    As a member of the short peptide bioregulator family developed by the St. Petersburg Institute of Bioregulation and Gerontology, Ovagen is investigated for its selectivity toward hepatocyte and liver tissue signaling models. Ovagen has been studied in preclinical liver models for its role in liver cell regeneration, protective effects under toxic challenge, and normalization of hepatic gene expression patterns associated with aging. Researchers use Ovagen in HepG2, HepaRG, and primary hepatocyte cultures to examine hepatic acute-phase response signaling (IL-6/CRP pathway), cytochrome P450 (CYP3A4/CYP2D6) enzyme expression, Nrf2/HO-1 oxidative stress pathway activation, and cellular apoptosis markers under standardized toxic challenge conditions.

    COMMON RESEARCH APPLICATIONS

    Hepatocyte Cytoprotection & Liver Injury Models
    Ovagen is examined in HepG2, HepaRG, and primary hepatocyte models under CCl₄, D-galactosamine, or tBHP challenge to study hepatocellular viability, caspase-3/7 apoptosis markers, Bcl-2/Bax ratio changes, and liver injury endpoint characterization.

    Cytochrome P450 Expression & Hepatic Drug Metabolism
    Used in HepaRG and primary hepatocyte cultures to characterize effects on CYP3A4, CYP2D6, and CYP1A2 expression under toxic challenge conditions as markers of hepatic drug-metabolizing enzyme maintenance and liver functional integrity.

    Hepatic Oxidative Stress & Nrf2 Pathway Research
    Examined in oxidative stress models (H₂O₂, tBHP) to study Nrf2/HO-1/NQO1 pathway activation, GSH/GSSG ratio changes, and superoxide dismutase (SOD2) expression as hepatocellular antioxidant defense endpoint markers.

    Comparative Khavinson Hepatic Peptide Screening
    Benchmarked alongside Livagen (Lys-Glu-Asp-Pro) to characterize tissue-selective hepatocyte vs. immune signaling profiles and distinct vs. shared signaling features between the two hepatic-targeted short peptide bioregulators.

  • Chemical Identity

    Compound Name: Ovagen

    Internal Catalog Code: Ovagen

    CAS Number: 135537-14-3

    Molecular Formula: C20H35N7O6

    Molecular Weight: 469.54 g/mol

    Physical Properties

    Form/Appearance: Lyophilized powder

    Quality & Testing

    Purity: As listed on lot-specific COA

    Testing Method : HPLC (as applicable) · identity confirmation per COA

    Verification

    COA: Lot-specific, included with order (QR on label)

    Handling & Storage

    Storage Temperature: Store desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.

    Light Sensitivity: Protect from light

    Moisture: Store desiccated when applicable

    Available Strengths: 20 mg

    SKU (20 mg): VE-OVAG-020

    • What is this product?
      Ovagen (CAS 135537-14-3, MW 469.54 g/mol, C₂₀H₃₅N₇O₆) is a synthetic Ile-Glu-Asp-Glu tetrapeptide from the Khavinson bioregulator series, supplied as a lyophilized powder for laboratory research use only. It is studied as a model hepatic cytoprotective peptide. Available as VE-OVAG-020 (20 mg).
    • What purity and testing methods are used?
      Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity with sequence verification. A lot-specific COA is included with every order, accessible via QR code on the label.
    • What are the key chemical identifiers?
      CAS 135537-14-3 · Molecular formula C₂₀H₃₅N₇O₆ · MW 469.54 g/mol · Sequence: Ile-Glu-Asp-Glu · Synonyms: IEDE, Khavinson liver peptide, hepatic cytoprotective tetrapeptide, Ovagen liver bioregulator.
    • What signaling pathways does Ovagen address in research models?
      Ovagen is studied in hepatocyte and liver tissue models for: Nrf2/HO-1/NQO1 oxidative stress pathway activation, cytochrome P450 enzyme expression (CYP3A4, CYP2D6, CYP1A2) under challenge conditions, IL-6/STAT3 hepatic acute-phase response, and Bcl-2/Bax apoptosis balance under toxic stress models.
    • How is Ovagen reconstituted for research use?
      Dissolve in sterile water or PBS (pH 7.0) at ~5 mg/mL. Use immediately or aliquot and store at −80°C. Avoid repeated freeze-thaw cycles. Protect from light.
    • What is the recommended storage upon receipt?
      Store immediately at −20°C desiccated. Short-term at 2–8°C acceptable for up to 2 weeks. Inspect vials for integrity upon receipt.
    • What is a COA and why does it matter?
      A COA documents lot-specific purity (HPLC ≥98%), sequence verification (MS: Ile-Glu-Asp-Glu confirmed), and appearance. Each Ovagen lot ships with a QR-accessible COA. Review before use to confirm identity and purity meet your experimental requirements.

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