MOTS-C
MOTS-C - Image 2

MOTS-C

Price range: $42.00 through $110.00

MOTS-c | Mitochondrial-Derived Peptide

Mitochondrial Signaling & Metabolic Research

MOTS-c is a mitochondrial-derived peptide commonly referenced in metabolic
signaling studies, mitochondrial communication research, cellular energy
pathway analysis, and stress response models.

In plain terms: MOTS-c is used in lab studies to observe how mitochondria (the powerhouses of the cell) send signals to manage energy use and metabolism.

  • 40 mg lyophilized research peptide
  • ≥98% purity by HPLC analysis
  • Lot-specific COA and laboratory documentation available

Research Use Only — Not for Human Consumption.

SKU: VE-MOTS Category:

Description

  • About MOTS-c (Mitochondrial ORF of the Twelve S rRNA type-c)

    MOTS-c — Mitochondrial ORF of the Twelve S rRNA type-c (CAS 1627580-12-4) — is a 16-amino acid mitochondria-derived peptide (MDP) encoded within the 12S rRNA gene of the mitochondrial genome. It represents a newly recognized class of bioactive peptides that are translated from mitochondrial DNA and regulate nuclear gene expression, a phenomenon termed mitochondrial-nuclear cross-talk (retrograde signaling).

    MOTS-c activates AMPK and inhibits the folate cycle to generate AICAR (ZMP), directly linking mitochondrial signaling to AMPK-mediated metabolic regulation. It translocates to the nucleus under metabolic stress conditions and modulates adaptive nuclear gene expression. Supplied as lyophilized peptide for non-clinical research use only.

    COMMON RESEARCH APPLICATIONS

    Mitochondrial-Nuclear Retrograde Signaling
    MOTS-c translocates to the nucleus under stress, activating AMPK-target gene networks. Used in stress-challenge models (glucose deprivation, oxidative stress) to study mitochondrial-nuclear communication in HEK293, HepG2, and C2C12 cell lines.

    AMPK Activation via Folate Cycle Inhibition
    MOTS-c inhibits the folate cycle, generating AICAR (ZMP) to activate AMPK. Used alongside direct AICAR and AMPK activators (metformin, A769662) to compare mitochondrial-origin vs. pharmacological AMPK activation in metabolic models.

    Metabolic Flexibility & Insulin Sensitivity Research
    Studied for effects on glucose uptake, fatty acid oxidation, and mitochondrial biogenesis in skeletal muscle (C2C12) and adipocyte models; used in insulin resistance challenge systems alongside AICAR and resveratrol.

    Aging Biology & Longevity Research
    Circulating MOTS-c levels decline with age. Used in senescence models to study age-related mitochondrial dysfunction, mitohormesis pathways, and the relationship between mitochondrial peptide signaling and cellular aging markers.

  • Chemical Identity

    Compound Name: MOTS-c

    Synonyms: Mitochondrial ORF of the Twelve S rRNA-c · mitochondrial-derived peptide MOTS-c · MRPS12-encoded peptide

    CAS Number: 1627580-12-4

    EC Number: N/A (mitochondria-encoded peptide)

    Molecular Formula: C₁₁₇H₂₀₈N₄₀O₃₃S

    Molecular Weight: 2288.60 g/mol

    Physical Properties

    Appearance: White lyophilized powder

    Solubility (water): ~1 mg/mL in sterile water or PBS (pH 7.4)

    Solubility (organic): Limited; DMSO not recommended

    Hygroscopic: Yes — store desiccated

    Quality & Testing

    Purity: ≥98% (HPLC)

    Testing Method : Reverse-phase HPLC · MS confirmation · sequence verification

    Verification

    COA: Lot-specific, included with order (QR on label)

    SDS Supplier : See SDS/MSDS · OSHA HCS / GHS compliant

    Handling & Storage

    Storage Temperature: Store desiccated at −20°C long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling.

    Light Sensitivity: Protect from light

    Reconstitution: Dissolve in sterile water or PBS (pH 7.4) at ~1 mg/mL; aliquot and store at −80°C

    Available Strengths: 10 mg

    SKU (10 mg): VE-MOTS-010

    • What is this product?
      MOTS-c is supplied as a lyophilized 16-amino acid mitochondria-derived peptide (CAS 1627580-12-4, MW 2288.60 g/mol) for laboratory research use only. It is encoded in mitochondrial DNA and represents a novel class of mitochondrial-origin bioactive peptides.
    • What purity and testing methods are used?
      Each lot is tested by reverse-phase HPLC and MS confirmation to ≥98% purity with sequence verification. A lot-specific COA is included with every order, accessible via QR code on the label.
    • What are the key chemical identifiers?
      CAS 1627580-12-4 · Molecular formula C₁₁₇H₂₀₈N₄₀O₃₃S · MW 2288.60 g/mol · Synonyms: Mitochondrial ORF of the Twelve S rRNA-c, MRPS12-encoded peptide, mitochondrial-derived peptide MOTS-c.
    • How is MOTS-c reconstituted for research use?
      Dissolve in sterile water or PBS (pH 7.4) at ~1 mg/mL. Aliquot and store at −80°C for long-term stability. Avoid repeated freeze-thaw cycles. DMSO is not recommended.
    • What is the recommended storage upon receipt?
      Store immediately at −20°C desiccated. For long-term stability, aliquot and store at −80°C. Short-term at 2–8°C is acceptable. Inspect vials for integrity upon receipt.
    • What is a COA and why does it matter?
      A COA documents lot-specific purity (HPLC ≥98%), sequence verification (MS), and appearance. Each MOTS-c lot ships with a QR-accessible COA. Review before use to confirm identity and purity.

  • PubMed Literature Search — MOTS-c
    Primary literature · 150+ indexed studies (emerging peptide class)
    Open PubMed

    PubChem Compound Record
    CAS 1627580-64-6 · Full chemical data, bioassays, patents
    View Record

    Supplier Product Insert / Technical Data Sheet
    Solubility data, storage protocol, sequence verification
    Download PDF

Additional information

Dosage

10mg, 40mg

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