SS-31
SS-31 - Image 2

SS-31

$74.00

SS-31 | Mitochondrial Target Peptide

Mitochondrial Function & Cellular Aging Research

SS-31 (Elamipretide) is a synthetic peptide commonly referenced in mitochondrial bioenergetics, oxidative stress reduction, cellular ATP synthesis pathway analysis, and cardioprotection models.

In plain terms: SS-31 is used in lab research to look at how cells protect their mitochondria from oxidative damage and keep producing energy efficiently.

  • Lyophilized research peptide
  • ≥98% purity by HPLC analysis
  • Lot-specific COA and laboratory documentation available

Research Use Only — Not for Human Consumption.

SKU: VE-SS31 Category:

Description

  • SS-31

    SS-31 — D-Arg-Dmt-Lys-Phe-NH₂ (CAS 736992-21-5) — is a cell-permeable, mitochondria-targeted tetrapeptide studied as a cardiolipin-binding tool compound for inner mitochondrial membrane bioenergetics research. It is supplied as a laboratory-grade lyophilized powder intended strictly for analytical and non-clinical research applications.

    SS-31's amphipathic structure and net +3 charge at physiological pH drive selective accumulation at the inner mitochondrial membrane (IMM), where it binds cardiolipin with high affinity. Researchers use SS-31 in isolated mitochondria, cell-based, and ex vivo models to examine cardiolipin–cytochrome c interaction stabilization, ETC supercomplex assembly, mitochondrial ROS suppression, and ATP synthesis efficiency under oxidative or ischemic stress conditions.

    COMMON RESEARCH APPLICATIONS

    Mitochondrial Bioenergetics & ETC Supercomplex Research
    SS-31 is used in isolated mitochondria and cell-based models to study cardiolipin-dependent stabilization of ETC supercomplexes (respirasomes), cytochrome c retention at the IMM, and ATP synthase activity preservation under oxidative or bioenergetic stress conditions.

    Ischemia-Reperfusion Injury Models
    Applied in cardiac, renal, and cerebral I/R models to examine mitochondrial ROS attenuation, membrane potential preservation (ΔΨm), and ATP recovery kinetics following simulated ischemia-reperfusion challenge in cardiomyocyte and tubular epithelial cell lines.

    Mitochondrial ROS & Oxidative Stress Assays
    Used in MitoSOX and DHE superoxide detection assays and H₂O₂ challenge models to quantify SS-31's effect on mitochondrial superoxide production and cardiolipin peroxidation under pro-oxidant and bioenergetically compromised conditions.

    Aging & Mitochondrial Dysfunction Models
    Benchmarked in aged-cell and senescence models to study mitochondrial cristae morphology, cardiolipin remodeling, and bioenergetic efficiency as endpoints in age-related mitochondrial decline and sarcopenia research.

  • Chemical Identity

    Compound Name: SS-31

    Synonyms: Elamipretide · MTP-131 · Bendavia · D-Arg-Dmt-Lys-Phe-NH₂

    CAS Number: 736992-21-5

    EC Number: N/A (synthetic tetrapeptide)

    Molecular Formula: C₃₂H₄₉N₉O₅

    Molecular Weight: 639.79 g/mol

    Physical Properties

    Appearance: White to off-white lyophilized powder

    Solubility (water): ≥50 mg/mL in sterile water or normal saline

    Solubility (organic): Slight DMSO solubility; aqueous reconstitution preferred

    Hygroscopic: Yes — store desiccated

    Quality & Testing

    Purity: ≥98% (HPLC)

    Testing Method: Reverse-phase HPLC · MS confirmation of peptide sequence

    Verification

    COA: Lot-specific, included with order (QR on label)

    SDS Supplier: Velox Research Chemicals

    SDS Revision: Current lot · OSHA HCS / GHS compliant

    Handling & Storage

    Storage Temperature: Store desiccated at −20°C for long-term; 2–8°C short-term. Protect from light. Refer to SDS/COA for compound-specific handling

    Light Sensitivity: Minimal; primary precaution is desiccated storage

    Reconstitution: Dissolve in sterile water or normal saline at ≥50 mg/mL; use immediately or aliquot at −80°C

    Available Strengths: 5 mg · 10 mg

    SKU (5 mg): VE-SS31-005

    SKU (10 mg): VE-SS31-010

    • What is this product?
      SS-31 (CAS 736992-21-5, MW 639.79 g/mol) is a synthetic, cell-permeable tetrapeptide (D-Arg-Dmt-Lys-Phe-NH₂) that selectively accumulates at the inner mitochondrial membrane via high-affinity cardiolipin binding. Supplied as a lyophilized powder for laboratory research use only. Also known as elamipretide, MTP-131, and Bendavia.
    • What purity and testing methods are used?
      Each lot is tested by reverse-phase HPLC to ≥98% purity, with MS confirmation of peptide identity and ICP analysis to verify copper stoichiometry. A lot-specific COA is included with every order, accessible via QR code on the label.
    • What are the key chemical identifiers?
      CAS 736992-21-5 · Molecular formula C₃₂H₄₉N₉O₅ · MW 639.79 g/mol · Synonyms: Elamipretide, MTP-131, Bendavia, D-Arg-Dmt-Lys-Phe-NH₂.
    • What signaling pathways does SS-31 address in research models?
      SS-31 research focuses on cardiolipin–cytochrome c interaction stabilization at the IMM, ETC supercomplex (respirasome) assembly, mitochondrial superoxide suppression, and ATP synthesis capacity under ischemic and oxidative stress conditions. Models include isolated mitochondria bioenergetic assays, I/R challenge in cardiomyocytes and renal tubular cells, and aging/sarcopenia cell models.
    • How is SS-31 reconstituted for research use?
      Dissolve in sterile water or PBS (pH 7.0) at ~5 mg/mL. Use immediately or aliquot and store at −80°C. Avoid repeated freeze-thaw cycles and protect from light to prevent copper-peptide complex degradation.
    • What is the recommended storage upon receipt?
      Store immediately at −20°C desiccated. Short-term at 2–8°C is acceptable for up to 2 weeks. The copper chelate is sensitive to moisture and light; inspect vials for colour integrity (blue-green) upon receipt.
    • What is a COA and why does it matter?
      A COA documents lot-specific purity (HPLC ≥98%), peptide identity (MS), copper content (ICP), and appearance. Each lot ships with a QR-accessible COA. Review before use to confirm identity, purity, and copper stoichiometry meet your experimental requirements.
    • What signaling pathways does SS-31 address in research models?
      SS-31 research focuses on cardiolipin–cytochrome c interaction stabilization at the IMM, ETC supercomplex (respirasome) assembly, mitochondrial superoxide suppression, and ATP synthesis capacity under ischemic and oxidative stress conditions. Models include isolated mitochondria bioenergetic assays, I/R challenge in cardiomyocytes and renal tubular cells, and aging/sarcopenia cell models.

  • PubMed Literature Search — SS-31
    Primary literature · curated search
    Open PubMed

    PubChem Compound Record Full chemical data, bioassays, patents
    View Record

    Source Document / Insert
    Supplier insert or supporting SDS source
    Download PDF

Additional information

Dosage

10mg, 50mg

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